Technology Process of tert-butyl 7-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate
There total 4 articles about tert-butyl 7-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
acetonitrile;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogen; palladium 10% on activated carbon / water; ethanol / 16 h / 20 °C / 760.05 Torr
2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 20 °C
With
palladium 10% on activated carbon; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
ethanol; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium tetrahydroborate; water / tetrahydrofuran / 0 - 20 °C / Reflux
2: hydrogen; palladium 10% on activated carbon / water; ethanol / 16 h / 20 °C / 760.05 Torr
3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 20 °C
With
sodium tetrahydroborate; palladium 10% on activated carbon; water; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; ethanol; water; acetonitrile;
