7-BENZYL-3-BOC-3,7-DIAZABICYCLO[3.3.1]NONANE

Base Information

• Chemical Name: 7-BENZYL-3-BOC-3,7-DIAZABICYCLO[3.3.1]NONANE
• CAS No.: 227940-71-8
• Molecular Formula: C19H28 N2 O2
• Molecular Weight: 316.444
• Hs Code.: 2933990090
• Mol file: 227940-71-8.mol

Synonyms:3-Benzyl-7-tert-butoxycarbonyl-3,7-diazabicyclo[3.3.1]nonane;tert-Butyl 7-benzyl-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

Chemical Property of 7-BENZYL-3-BOC-3,7-DIAZABICYCLO[3.3.1]NONANE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 62-65℃
• Refractive Index: 1.547
• Boiling Point: 409.1°Cat760mmHg
• PKA: 8.13±0.20(Predicted)
• Flash Point: 201.2°C
• PSA: 32.78000
• Density: 1.097g/cm³
• LogP: 3.25120
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl7-Benzyl-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: tert-Butyl 7-Benzyl-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate is a reactant used in the preparation of chiral phosphoramidite ligands for enantioselective conjugate addition reactions.

Technology Process of 7-BENZYL-3-BOC-3,7-DIAZABICYCLO[3.3.1]NONANE

There total 6 articles about 7-BENZYL-3-BOC-3,7-DIAZABICYCLO[3.3.1]NONANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-benzyl-3,7-diaza-bicyclo[3,3,1]nonane (69407-32-5) → tert-Butyl 7-benzyl-3,7-diazabicyclo[3.3. 1]-nonane-3-carboxylate (227940-71-8)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

Reference yield: 100.0%

3-benzyl-3,7-diaza-bicyclo[3,3,1]nonane (69407-32-5) → tert-Butyl 7-benzyl-3,7-diazabicyclo[3.3. 1]-nonane-3-carboxylate (227940-71-8)

Guidance literature:

With di-tert-butyl dicarbonate; In tetrahydrofuran;

Reference yield: 85.0%

7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester (227940-70-7) → tert-Butyl 7-benzyl-3,7-diazabicyclo[3.3. 1]-nonane-3-carboxylate (227940-71-8)

Guidance literature:

7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester; With hydrazine hydrate; In diethylene glycol; at 60 ℃; for 0.166667h;

With potassium hydroxide; In diethylene glycol; at 160 ℃; for 8h;

DOI:10.1016/j.tetlet.2011.11.112

upstream raw materials:

7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester

di-tert-butyl dicarbonate

3-benzyl-3,7-diaza-bicyclo[3,3,1]nonane

toluene-4-sulfonic acid hydrazide

Downstream raw materials:

3,7-diazabicyclo{3.3.1}nonane

tert-butyl 7-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

(7-(5-chlorobenzo[d]oxazol-2-yl)-3,7-diazabicyclo[3.3.1]nonan-3-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone