(7-(5-chlorobenzo[d]oxazol-2-yl)-3,7-diazabicyclo[3.3.1]nonan-3-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Base Information

• Chemical Name: (7-(5-chlorobenzo[d]oxazol-2-yl)-3,7-diazabicyclo[3.3.1]nonan-3-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone
• CAS No.: 1429773-09-0
• Molecular Formula: C₂₄H₂₃ClN₆O₂
• Molecular Weight: 462.939
• Mol file: 1429773-09-0.mol

Synonyms:(7-(5-chlorobenzo[d]oxazol-2-yl)-3,7-diazabicyclo[3.3.1]nonan-3-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Chemical Property of (7-(5-chlorobenzo[d]oxazol-2-yl)-3,7-diazabicyclo[3.3.1]nonan-3-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (7-(5-chlorobenzo[d]oxazol-2-yl)-3,7-diazabicyclo[3.3.1]nonan-3-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

There total 6 articles about (7-(5-chlorobenzo[d]oxazol-2-yl)-3,7-diazabicyclo[3.3.1]nonan-3-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-dichloro-1,3-benzoxazole (3621-81-6) + 3,7-diazabicyclo[3.3.1]nonan-3-yl(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)-methanone?hydrochloride → (7-(5-chlorobenzo[d]oxazol-2-yl)-3,7-diazabicyclo[3.3.1]nonan-3-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone (1429773-09-0)

Guidance literature:

With potassium carbonate; In o-xylene; for 0.5h; Reflux;

Reference yield:

tert-Butyl 7-benzyl-3,7-diazabicyclo[3.3. 1]-nonane-3-carboxylate (227940-71-8) → (7-(5-chlorobenzo[d]oxazol-2-yl)-3,7-diazabicyclo[3.3.1]nonan-3-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone (1429773-09-0)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogen; palladium 10% on activated carbon / water; ethanol / 16 h / 20 °C / 760.05 Torr

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 20 °C

3: hydrogenchloride / 2 h / 20 °C

4: potassium carbonate / o-xylene / 0.5 h / Reflux

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In ethanol; o-xylene; water; acetonitrile;

Reference yield:

7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester (227940-70-7) → (7-(5-chlorobenzo[d]oxazol-2-yl)-3,7-diazabicyclo[3.3.1]nonan-3-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone (1429773-09-0)

Guidance literature:

Multi-step reaction with 6 steps

1: ethanol / 1 h / 95 °C

2: sodium tetrahydroborate; water / tetrahydrofuran / 0 - 20 °C / Reflux

3: hydrogen; palladium 10% on activated carbon / water; ethanol / 16 h / 20 °C / 760.05 Torr

4: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 20 °C

5: hydrogenchloride / 2 h / 20 °C

6: potassium carbonate / o-xylene / 0.5 h / Reflux

With hydrogenchloride; sodium tetrahydroborate; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; o-xylene; water; acetonitrile;

upstream raw materials:

tert-Butyl 7-benzyl-3,7-diazabicyclo[3.3. 1]-nonane-3-carboxylate

tert-Butyl 3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

tert-butyl 7-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

2,5-dichloro-1,3-benzoxazole