7-BENZYL-3-BOC-3,7-DIAZABICYCLO[3.3.1]NONAN-9-ONE

Base Information

• Chemical Name: 7-BENZYL-3-BOC-3,7-DIAZABICYCLO[3.3.1]NONAN-9-ONE
• CAS No.: 227940-70-7
• Molecular Formula: C19H26 N2 O3
• Molecular Weight: 330.427
• Hs Code.: 2933990090
• Mol file: 227940-70-7.mol

Synonyms:tert-Butyl7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

Chemical Property of 7-BENZYL-3-BOC-3,7-DIAZABICYCLO[3.3.1]NONAN-9-ONE

Chemical Property:

• Boiling Point: 455.9°Cat760mmHg
• Flash Point: 229.5°C
• PSA: 49.85000
• Density: 1.16g/cm³
• LogP: 2.43020
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-BENZYL-3-BOC-3,7-DIAZABICYCLO[3.3.1]NONAN-9-ONE

There total 5 articles about 7-BENZYL-3-BOC-3,7-DIAZABICYCLO[3.3.1]NONAN-9-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + benzylamine (100-46-9) → 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester (227940-70-7)

Guidance literature:

With acetic acid; In methanol; for 4h; Heating / reflux;

Reference yield: 70.0%

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + benzylamine (100-46-9) → 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester (227940-70-7)

Guidance literature:

With formaldehyd; acetic acid; In ethanol; water; toluene;

Reference yield: 70.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + acetic acid (64-19-7,77671-22-8) + benzylamine (100-46-9) → 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester (227940-70-7)

Guidance literature:

In ethanol; at 65 ℃; for 2h;

upstream raw materials:

formaldehyd

N-tert-butyloxycarbonylpiperidin-4-one

benzylamine

acetic acid

Downstream raw materials:

3-(tert-butyloxycarbonyl)-7-benzyl-9-(4'-carboxybutylidene)-3,7-diazabicyclo[3.3.1]nonane

tert-Butyl 7-benzyl-3,7-diazabicyclo[3.3. 1]-nonane-3-carboxylate

tert-Butyl 3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

7-benzyl-9-(4-methoxycarbonyl-butylidene)-3,7-diaza-bicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester