4-((6-(5-methyl-2,4-dioxo-3,4-dihydro pyrimidin-1(2H)-yl)hexyl)oxy)benzaldehyde

Base Information

• Chemical Name: 4-((6-(5-methyl-2,4-dioxo-3,4-dihydro pyrimidin-1(2H)-yl)hexyl)oxy)benzaldehyde
• CAS No.: 1402591-96-1
• Molecular Formula: C₁₈H₂₂N₂O₄
• Molecular Weight: 330.384
• Mol file: 1402591-96-1.mol

Synonyms:4-((6-(5-methyl-2,4-dioxo-3,4-dihydro pyrimidin-1(2H)-yl)hexyl)oxy)benzaldehyde

Chemical Property of 4-((6-(5-methyl-2,4-dioxo-3,4-dihydro pyrimidin-1(2H)-yl)hexyl)oxy)benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((6-(5-methyl-2,4-dioxo-3,4-dihydro pyrimidin-1(2H)-yl)hexyl)oxy)benzaldehyde

There total 2 articles about 4-((6-(5-methyl-2,4-dioxo-3,4-dihydro pyrimidin-1(2H)-yl)hexyl)oxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

thymin (65-71-4,28806-14-6,691841-57-3) + 4-((6-bromohexyl)oxy)benzaldehyde (141823-14-5) → 4-((6-(5-methyl-2,4-dioxo-3,4-dihydro pyrimidin-1(2H)-yl)hexyl)oxy)benzaldehyde (1402591-96-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 72h; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.11.131

Reference yield:

1 ,6-dibromohexane (629-03-8) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-((6-(5-methyl-2,4-dioxo-3,4-dihydro pyrimidin-1(2H)-yl)hexyl)oxy)benzaldehyde (1402591-96-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 24 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C / Inert atmosphere

With potassium carbonate; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.tetlet.2012.11.131

Reference yield: 67.0%

4-((6-(5-methyl-2,4-dioxo-3,4-dihydro pyrimidin-1(2H)-yl)hexyl)oxy)benzaldehyde (1402591-96-1) + tetramethyl (((6-(4-(4-(bis(4-(diphenylamino)phenyl)amino)styryl)phenyl)-1,3,5-triazine-2,4-diyl)bis(4,1-phenylene))bis(methylene))bis(phosphonate)nd (1421017-07-3) → 1,1'-(((((1E,1'E)-((6-(4-((E)-4-(bis(4-(diphenylamino)phenyl)amino)styryl)phenyl)-1,3,5-triazine-2,4-diyl)bis(4,1-phenylene))bis(ethene-2,1-diyl))bis(4,1-phenylene))bis(oxy))bis(hexane-6,1-diyl))bis(5-methylpyrimidine-2,4(1H,3H)-dione) (1421017-08-4)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In dichloromethane; at 45 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.11.131

upstream raw materials:

thymin

4-((6-bromohexyl)oxy)benzaldehyde

1 ,6-dibromohexane

4-hydroxy-benzaldehyde

Downstream raw materials:

1,1'-(((((1E,1'E)-((6-(4-((E)-4-(bis(4-(diphenylamino)phenyl)amino)styryl)phenyl)-1,3,5-triazine-2,4-diyl)bis(4,1-phenylene))bis(ethene-2,1-diyl))bis(4,1-phenylene))bis(oxy))bis(hexane-6,1-diyl))bis(5-methylpyrimidine-2,4(1H,3H)-dione)