Trospium chloride

Base Information

• Chemical Name: Trospium chloride
• CAS No.: 10405-02-4
• Deprecated CAS: 1001323-19-8
• Molecular Formula: C25H30NO3
• Molecular Weight: 427.971
• Hs Code.: 2939800000
• European Community (EC) Number: 233-875-4
• UNII: 1E6682427E
• Wikipedia: Trospium_chloride
• Wikidata: Q27252312
• NCI Thesaurus Code: C61995
• RXCUI: 38891
• Pharos Ligand ID: 8LF527XK4AV9
• ChEMBL ID: CHEMBL3084748
• Mol file: 10405-02-4.mol

Synonyms:azoniaspiro compound XVII;azoniaspiro(3 alpha-benziloyloxynortropane-8,1'- pyrrolidine) chloride;Ceris;Spasmex;Spasmo-lyt;Spasmo-Rhoival TC;Spasmo-Urgenin;Spasmo-Urgenin TC;Spasmolyt;Trospi;trospium chloride;Uraplex;Uraton

Chemical Property of Trospium chloride

Chemical Property:

• Appearance/Colour: white to off-white powder
• Melting Point: 266-268 °C
• PSA: 46.53000
• LogP: 0.73250
• Storage Temp.: -20?C Freezer
• Solubility.: Very soluble in water, freely soluble in methanol, practically insoluble in methylene chloride.
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 427.1914215
• Heavy Atom Count: 30
• Complexity: 553

Purity/Quality:

99% ^*data from raw suppliers

Trospium Chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC[N+]2(C1)C3CCC2CC(C3)OC(=O)C(C4=CC=CC=C4)(C5=CC=CC=C5)O.[Cl-]
• Isomeric SMILES: C1CC[N+]2(C1)[C@@H]3CC[C@H]2CC(C3)OC(=O)C(C4=CC=CC=C4)(C5=CC=CC=C5)O.[Cl-]
• Recent ClinicalTrials: Trospium Chloride vs Tamsulosin in Treatment of Ureteral Stent Related Symptoms:
• Recent EU Clinical Trials: An Open Label Extension Study to Assess the Long-term Safety and Tolerability of Adjunctive KarXT in Subjects with Inadequately Controlled Symptoms of Schizophrenia
• Description: Trospium chloride (Sanctura) is an antimuscarinic that has been used in Europe for the management of OAB symptoms for over 30 years.Trospium chloride's chemical structure is such that it is unlikely to penetrate the brain and thus does not appear to affect cognitive function. Trospium chloride is usually administered orally twice a day in 20mg. Trospium chloride should be taken 1 hour before meals or on an empty stomach. It is not well absorbed if taken with food.An advantage of this medication is that it has little potential interaction with other medications.
• Uses: Tropine derivative with anticholinergic activity, Trospium chloride can be used as Antispasmodic and used in treatment of urinary incontinence An antimuscarinic compound that inhibits mAChR M Labeled Trospium, intended for use as an internal standard for the quantification of Trospium by GC- or LC-mass spectrometry.
• Therapeutic Function: Anticholinergic, Spasmolytic
• Clinical Use: Antimuscarinic: Symptomatic treatment of urinary incontinence, frequency or urgency
• Drug interactions: Potentially hazardous interactions with other drugs Anti-arrhythmics: increased risk of antimuscarinic side effects with disopyramide.

Technology Process of Trospium chloride

There total 2 articles about Trospium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

Trospium spiroalcohol (3464-71-9) + Benzilic acid imidazolide (15441-11-9) → trospium chloride (10405-02-4)

Guidance literature:

dmap; In N,N-dimethyl-formamide; at 80 ℃; for 1.08333h; Product distribution / selectivity;

Reference yield:

→ trospium chloride (10405-02-4)

Guidance literature:

Reference yield:

lauryl sulfate (557-47-1) + trospium chloride (10405-02-4) → C25H30NO3(1+)*C12H25O4S(1-)

Guidance literature:

In chloroform; water; for 24h;

upstream raw materials:

Trospium spiroalcohol

Benzilic acid imidazolide

Refernces

• 1、 -. "Pharmaceutical composition using a mixture of propellant gases for a metered dose inhaler". . . Retrieved 2008/06/13.