6-HYDROXY-2-METHYLAMINOPURINE

Base Information

• Chemical Name: 6-HYDROXY-2-METHYLAMINOPURINE
• CAS No.: 10030-78-1
• Molecular Formula: C6H7 N5 O
• Molecular Weight: 165.15
• Hs Code.: 2933990090
• Mol file: 10030-78-1.mol

Synonyms:6H-Purin-6-one,1,7-dihydro-2-(methylamino)- (9CI); Guanine, N-methyl- (6CI,7CI,8CI);2-(Methylamino)-6-hydroxypurine; 2-Methylamino-6-oxopurine;6-Hydroxy-2-(methylamino)purine; N2-Methylguanine; NSC 90400

Chemical Property of 6-HYDROXY-2-METHYLAMINOPURINE

Chemical Property:

• Vapor Pressure: 0.00389mmHg at 25°C
• Boiling Point: 488.2°Cat760mmHg
• Flash Point: 249.1°C
• PSA: 86.72000
• Density: 1.79g/cm³
• LogP: 0.17320
• Storage Temp.: 4°C, Inert atmosphere

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Methylamino)-6,7-dihydro-3H-purin-6-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-HYDROXY-2-METHYLAMINOPURINE

There total 8 articles about 6-HYDROXY-2-METHYLAMINOPURINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

tert-butyl 2-[(tert-butoxycarbonyl)(methyl)amino]-6-chloro-9H-purine-9-carboxylate → 2-methyamino-6-hydroxypurine (10030-78-1)

Guidance literature:

With formic acid; water; at 75 ℃; for 2h;

DOI:10.1134/S1070428019060198

Reference yield: 73.0%

7-Benzyl-2-methylamino-1,7-dihydro-purin-6-one → 1,7-dihydro-2-(methylamino)-6H-purin-6-one (10030-78-1)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In water; at 85 - 90 ℃;

DOI:10.1007/bf01169255

Reference yield:

2-methylsulfanyl-1,7(9)-dihydro-purin-6-one (5446-89-9) + methylamine (74-89-5) → 1,7-dihydro-2-(methylamino)-6H-purin-6-one (10030-78-1)

Guidance literature:

With water; at 140 ℃;

DOI:10.1021/ja01582a060

upstream raw materials:

2-methylsulfanyl-1,7⁽⁹⁾-dihydro-purin-6-one

methylamine

7-benzyl-2-chloro-1,7-dihydro-purin-6-one

2-thioxanthine

Downstream raw materials:

N₂-Methylguanosine

2-methylamino-1,7-dihydro-purine-6-thione

Refernces

• 1、 -. "Method for treating disease or condition susceptible to amelioration by AMPK activators and compounds of formula which are useful to activate AMP-activated protein kinase (AMPK)". Paragraph 0061-0062. . Retrieved 2014/10/16.