(R)-3-(4-fluorophenyl)-2-formylpentanedioic acid 1-methyl ester

Base Information

Chemical Name:(R)-3-(4-fluorophenyl)-2-formylpentanedioic acid 1-methyl ester
CAS No.:1224442-80-1
Molecular Formula:C₁₃H₁₃FO₅
Molecular Weight:268.242
Hs Code.:

Synonyms:(R)-3-(4-fluorophenyl)-2-formylpentanedioic acid 1-methyl ester

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Chemical Property of (R)-3-(4-fluorophenyl)-2-formylpentanedioic acid 1-methyl ester

Chemical Property:

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Technology Process of (R)-3-(4-fluorophenyl)-2-formylpentanedioic acid 1-methyl ester

There total 9 articles about (R)-3-(4-fluorophenyl)-2-formylpentanedioic acid 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-3-(4-fluorophenyl)pentanedioic acid monomethyl ester

: 201230-82-2
carbon monoxide

: 1224442-80-1
(R)-3-(4-fluorophenyl)-2-formylpentanedioic acid 1-methyl ester

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 50 ℃; under 30003 Torr;
DOI:10.1016/j.cclet.2013.04.009

Reference yield:

: (R)-3-(4-fluorophenyl)pentanedioic acid monomethyl ester

: 107-31-3
Methyl formate

: 1224442-80-1
(R)-3-(4-fluorophenyl)-2-formylpentanedioic acid 1-methyl ester

Guidance literature:: (R)-3-(4-fluorophenyl)pentanedioic acid monomethyl ester; With n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; at -55 - -45 ℃; for 1.16667h;

Methyl formate; In tetrahydrofuran; hexane; at -55 - -20 ℃; for 2h; regioselective reaction;
DOI:10.1016/j.tetlet.2010.01.049

Reference yield:

: 4926-12-9
4-(4-fluorophenyl)dihydropyran-2,6(3H)-dione

: 1224442-80-1
(R)-3-(4-fluorophenyl)-2-formylpentanedioic acid 1-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: C₄₀H₃₅F₆N₃O₅S / tert-butyl methyl ether

2: potassium tert-butylate / tetrahydrofuran / 50 °C / 30003 Torr

With C₄₀H₃₅F₆N₃O₅S; potassium tert-butylate; In tetrahydrofuran; tert-butyl methyl ether;
DOI:10.1016/j.cclet.2013.04.009