Betalone

Base Information

Chemical Name:Betalone
CAS No.:1247-42-3
Molecular Formula:C22H28O5
Molecular Weight:372.461
Hs Code.:2937290000
NSC Number:527579
DSSTox Substance ID:DTXSID70859608
Mol file:1247-42-3.mol

Synonyms:16-methylprednisone;Betapar;meprednisone

Suppliers and Price of Betalone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Meprednisone
10mg
$ 230.00

TRC
Meprednisone
5mg
$ 130.00

Medical Isotopes, Inc.
Meprednisone
10 mg
$ 620.00

DC Chemicals
Betapar(Meprednisone) >99%
250 mg
$ 550.00

DC Chemicals
Betapar(Meprednisone) >99%
1 g
$ 1100.00

Crysdot
Meprednisone 98+%
50mg
$ 1002.00

Crysdot
Meprednisone 98+%
25mg
$ 528.00

Crysdot
Meprednisone 98+%
10mg
$ 242.00

ChemScene
Meprednisone 99.60%
5mg
$ 60.00

ChemScene
Meprednisone 99.60%
10mg
$ 100.00

Total 121 raw suppliers

Chemical Property of Betalone

Chemical Property:

Appearance/Colour:white solid
Vapor Pressure:1.39E-15mmHg at 25°C
Melting Point:204-206 °C
Refractive Index:1.595
Boiling Point:574.4 °C at 760 mmHg
PKA:12.38±0.70(Predicted)
Flash Point:315.2 °C
PSA：91.67000
Density:1.28 g/cm³
LogP:2.01180
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:372.19367399
Heavy Atom Count:27
Complexity:795

Purity/Quality:

99% ^*data from raw suppliers

Meprednisone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC2C3CCC4=CC(=O)C=CC4(C3C(=O)CC2(C1(C(=O)CO)O)C)C
Recent EU Clinical Trials:Betamethasone (Betapred?) as premedication for reducing postoperative vomiting and pain after tonsillectomy – a randomized, double-blind, placebo-controlled trial
Uses Corticosteroid. Betapar(Meprednisone) is a glucocorticoid and a methylated derivative of prednisone. [1]The methylprednisone to MPL area under the curve ratio decreased from 0.19 +/- 0.04 in control to 0.14 +/- 0.03 in ketoconazole-treated rats (P less than .05) due to a
Therapeutic Function Glucocorticoid

Technology Process of Betalone

There total 11 articles about Betalone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1106-03-2
21-acetoxy-17-hydroxy-16β-methyl-pregna-1,4-diene-3,11,20-trione

: 1247-42-3
meprednisone

Guidance literature:: With sodium hydroxide; In ethanol; at 20 - 40 ℃; Solvent; Reagent/catalyst;

Reference yield: 72.5%

: C₂₆H₃₆O₆Si

: 75-16-1
methylmagnesium bromide

: 1247-42-3
meprednisone

Guidance literature:: C₂₆H₃₆O₆Si; methylmagnesium bromide; In tetrahydrofuran; at 50 - 55 ℃;

With hydrogenchloride; In water; at 25 - 55 ℃; Solvent; Reagent/catalyst;

Reference yield:

: 1253-36-7
21-acetoxy-17-hydroxy-16β-methyl-5β-pregnane-3,11,20-trione

: 1247-42-3
meprednisone

Guidance literature:: Multi-step reaction with 2 steps

1: ueber das 2,4-Dibrom-Derivat

2: aqueous methanol.KHCO₃

With potassium hydrogencarbonate;
DOI:10.1021/ja01549a086 DOI:10.1021/ja01549a095