ethyl 2-(N-((2-chloropyridin-3-yl)methyl)-4-methylphenylsulfonamido)acetate

Base Information

Chemical Name:ethyl 2-(N-((2-chloropyridin-3-yl)methyl)-4-methylphenylsulfonamido)acetate
CAS No.:1480815-20-0
Molecular Formula:C₁₇H₁₉ClN₂O₄S
Molecular Weight:382.868
Hs Code.:

Synonyms:ethyl 2-(N-((2-chloropyridin-3-yl)methyl)-4-methylphenylsulfonamido)acetate

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Chemical Property of ethyl 2-(N-((2-chloropyridin-3-yl)methyl)-4-methylphenylsulfonamido)acetate

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Technology Process of ethyl 2-(N-((2-chloropyridin-3-yl)methyl)-4-methylphenylsulfonamido)acetate

There total 3 articles about ethyl 2-(N-((2-chloropyridin-3-yl)methyl)-4-methylphenylsulfonamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1480815-18-6
ethyl 2-(((2-chloropyridin-3-yl)-methyl)amino)acetate

: 98-59-9
p-toluenesulfonyl chloride

: 1480815-20-0
ethyl 2-(N-((2-chloropyridin-3-yl)methyl)-4-methylphenylsulfonamido)acetate

Guidance literature:: With triethylamine; In dichloromethane; at 15 - 20 ℃; for 16h; Inert atmosphere; Large scale;
DOI:10.1021/op400228z

Reference yield:

: C₁₀H₁₁ClN₂O₂

: 1480815-20-0
ethyl 2-(N-((2-chloropyridin-3-yl)methyl)-4-methylphenylsulfonamido)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 15 - 20 °C / Molecular sieve; Large scale

2: triethylamine / dichloromethane / 16 h / 15 - 20 °C / Inert atmosphere; Large scale

With sodium tris(acetoxy)borohydride; triethylamine; In dichloromethane;
DOI:10.1021/op400228z

Reference yield:

: 36404-88-3
2-chloro-3-carbaldehydepyridine

: 1480815-20-0
ethyl 2-(N-((2-chloropyridin-3-yl)methyl)-4-methylphenylsulfonamido)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; acetic acid / dichloromethane / 15 - 20 °C / pH 6-7 / Molecular sieve; Large scale

2: sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 15 - 20 °C / Molecular sieve; Large scale

3: triethylamine / dichloromethane / 16 h / 15 - 20 °C / Inert atmosphere; Large scale

With sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In dichloromethane;
DOI:10.1021/op400228z