ethyl ethyl 3-((N-(2-ethoxy-2-oxoethyl)-4-methylphenylsulfonamido)methyl)picolinate

Base Information

Chemical Name:ethyl ethyl 3-((N-(2-ethoxy-2-oxoethyl)-4-methylphenylsulfonamido)methyl)picolinate
CAS No.:1480815-22-2
Molecular Formula:C₂₀H₂₄N₂O₆S
Molecular Weight:420.486
Hs Code.:

Synonyms:ethyl ethyl 3-((N-(2-ethoxy-2-oxoethyl)-4-methylphenylsulfonamido)methyl)picolinate

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Chemical Property of ethyl ethyl 3-((N-(2-ethoxy-2-oxoethyl)-4-methylphenylsulfonamido)methyl)picolinate

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Technology Process of ethyl ethyl 3-((N-(2-ethoxy-2-oxoethyl)-4-methylphenylsulfonamido)methyl)picolinate

There total 4 articles about ethyl ethyl 3-((N-(2-ethoxy-2-oxoethyl)-4-methylphenylsulfonamido)methyl)picolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.3%

: 64-17-5
ethanol

: 201230-82-2
carbon monoxide

: 1480815-20-0
ethyl 2-(N-((2-chloropyridin-3-yl)methyl)-4-methylphenylsulfonamido)acetate

: 1480815-22-2
ethyl ethyl 3-((N-(2-ethoxy-2-oxoethyl)-4-methylphenylsulfonamido)methyl)picolinate

Guidance literature:: With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine; at 15 - 100 ℃; for 16h; under 3878.71 Torr; Large scale;
DOI:10.1021/op400228z

Reference yield:

: 36404-88-3
2-chloro-3-carbaldehydepyridine

: 1480815-22-2
ethyl ethyl 3-((N-(2-ethoxy-2-oxoethyl)-4-methylphenylsulfonamido)methyl)picolinate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; acetic acid / dichloromethane / 15 - 20 °C / pH 6-7 / Molecular sieve; Large scale

2: sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 15 - 20 °C / Molecular sieve; Large scale

3: triethylamine / dichloromethane / 16 h / 15 - 20 °C / Inert atmosphere; Large scale

4: triethylamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate / 16 h / 15 - 100 °C / 3878.71 Torr / Large scale

With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In dichloromethane;
DOI:10.1021/op400228z

Reference yield:

: 1480815-18-6
ethyl 2-(((2-chloropyridin-3-yl)-methyl)amino)acetate

: 1480815-22-2
ethyl ethyl 3-((N-(2-ethoxy-2-oxoethyl)-4-methylphenylsulfonamido)methyl)picolinate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 16 h / 15 - 20 °C / Inert atmosphere; Large scale

2: triethylamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate / 16 h / 15 - 100 °C / 3878.71 Torr / Large scale

With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine; In dichloromethane;
DOI:10.1021/op400228z