2,5-bis((2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)ethynyl)pyrazine

Base Information

Chemical Name:2,5-bis((2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)ethynyl)pyrazine
CAS No.:1610927-93-9
Molecular Formula:C₅₀H₄₆F₆N₆O₈
Molecular Weight:972.941
Hs Code.:

Synonyms:2,5-bis((2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)ethynyl)pyrazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,5-bis((2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)ethynyl)pyrazine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2,5-bis((2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)ethynyl)pyrazine

There total 6 articles about 2,5-bis((2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)ethynyl)pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1610928-00-1
3-ethynyl-2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine

: 622392-04-5
2-bromo-5-iodo-pyrazine

: 1610927-93-9
2,5-bis((2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)ethynyl)pyrazine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 4.5h; Schlenk technique; Inert atmosphere;
DOI:10.1039/c4tc00234b

Reference yield:

: 1610927-97-3
4-(2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)-2-methylbut-3-yn-2-ol

: 1610927-93-9
2,5-bis((2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)ethynyl)pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / toluene / 2 h / 120 °C / Sealed tube; Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 4.5 h / 80 °C / Schlenk technique; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; triethylamine; sodium hydroxide; In N,N-dimethyl-formamide; toluene; 2: |Sonogashira Cross-Coupling;
DOI:10.1039/c4tc00234b

Reference yield:

: 74784-70-6
2-amino-5-trifluoromethylpyridine

: 1610927-93-9
2,5-bis((2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)ethynyl)pyrazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: iodine / neat (no solvent) / 19 h / 100 °C

1.2: 1.5 h / Reflux

2.1: N-Bromosuccinimide / acetonitrile / 1 h / 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride; trifluoroacetic acid; copper(l) iodide / N,N-dimethyl-formamide / 17 h / 80 °C / Inert atmosphere

4.1: sodium hydroxide / toluene / 2 h / 120 °C / Sealed tube; Inert atmosphere

5.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 4.5 h / 80 °C / Schlenk technique; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; copper(l) iodide; iodine; triethylamine; trifluoroacetic acid; sodium hydroxide; In N,N-dimethyl-formamide; toluene; acetonitrile; 3.1: |Sonogashira Cross-Coupling / 5.1: |Sonogashira Cross-Coupling;
DOI:10.1039/c4tc00234b