4-(2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)-2-methylbut-3-yn-2-ol

Base Information

Chemical Name:4-(2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)-2-methylbut-3-yn-2-ol
CAS No.:1610927-97-3
Molecular Formula:C₂₆H₂₉F₃N₂O₅
Molecular Weight:506.522
Hs Code.:

Synonyms:4-(2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)-2-methylbut-3-yn-2-ol

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Chemical Property of 4-(2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)-2-methylbut-3-yn-2-ol

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Technology Process of 4-(2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)-2-methylbut-3-yn-2-ol

There total 4 articles about 4-(2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)-2-methylbut-3-yn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1610928-02-3
3-bromo-2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine

: 115-19-5
2-methyl-but-3-yn-2-ol

: 1610927-97-3
4-(2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)-2-methylbut-3-yn-2-ol

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; trifluoroacetic acid; In N,N-dimethyl-formamide; at 80 ℃; for 17h; Inert atmosphere;
DOI:10.1039/c4tc00234b

Reference yield:

: 74784-70-6
2-amino-5-trifluoromethylpyridine

: 1610927-97-3
4-(2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)-2-methylbut-3-yn-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: iodine / neat (no solvent) / 19 h / 100 °C

1.2: 1.5 h / Reflux

2.1: N-Bromosuccinimide / acetonitrile / 1 h / 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride; trifluoroacetic acid; copper(l) iodide / N,N-dimethyl-formamide / 17 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; copper(l) iodide; iodine; trifluoroacetic acid; In N,N-dimethyl-formamide; acetonitrile; 3.1: |Sonogashira Cross-Coupling;
DOI:10.1039/c4tc00234b

Reference yield:

: 1-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)ethanone

: 1610927-97-3
4-(2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)-2-methylbut-3-yn-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: iodine / neat (no solvent) / 19 h / 100 °C

1.2: 1.5 h / Reflux

2.1: N-Bromosuccinimide / acetonitrile / 1 h / 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride; trifluoroacetic acid; copper(l) iodide / N,N-dimethyl-formamide / 17 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; copper(l) iodide; iodine; trifluoroacetic acid; In N,N-dimethyl-formamide; acetonitrile; 3.1: |Sonogashira Cross-Coupling;
DOI:10.1039/c4tc00234b