3-ethynyl-2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine

Base Information

Chemical Name:3-ethynyl-2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine
CAS No.:1610928-00-1
Molecular Formula:C₂₃H₂₃F₃N₂O₄
Molecular Weight:448.442
Hs Code.:

Synonyms:3-ethynyl-2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine

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Chemical Property of 3-ethynyl-2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine

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Technology Process of 3-ethynyl-2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine

There total 4 articles about 3-ethynyl-2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1610927-97-3
4-(2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl)-2-methylbut-3-yn-2-ol

: 1610928-00-1
3-ethynyl-2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine

Guidance literature:: With sodium hydroxide; In toluene; at 120 ℃; for 2h; Sealed tube; Inert atmosphere;
DOI:10.1039/c4tc00234b

Reference yield:

: 74784-70-6
2-amino-5-trifluoromethylpyridine

: 1610928-00-1
3-ethynyl-2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: iodine / neat (no solvent) / 19 h / 100 °C

1.2: 1.5 h / Reflux

2.1: N-Bromosuccinimide / acetonitrile / 1 h / 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride; trifluoroacetic acid; copper(l) iodide / N,N-dimethyl-formamide / 17 h / 80 °C / Inert atmosphere

4.1: sodium hydroxide / toluene / 2 h / 120 °C / Sealed tube; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; copper(l) iodide; iodine; trifluoroacetic acid; sodium hydroxide; In N,N-dimethyl-formamide; toluene; acetonitrile; 3.1: |Sonogashira Cross-Coupling;
DOI:10.1039/c4tc00234b

Reference yield:

: 1-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)ethanone

: 1610928-00-1
3-ethynyl-2-(4-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: iodine / neat (no solvent) / 19 h / 100 °C

1.2: 1.5 h / Reflux

2.1: N-Bromosuccinimide / acetonitrile / 1 h / 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride; trifluoroacetic acid; copper(l) iodide / N,N-dimethyl-formamide / 17 h / 80 °C / Inert atmosphere

4.1: sodium hydroxide / toluene / 2 h / 120 °C / Sealed tube; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; copper(l) iodide; iodine; trifluoroacetic acid; sodium hydroxide; In N,N-dimethyl-formamide; toluene; acetonitrile; 3.1: |Sonogashira Cross-Coupling;
DOI:10.1039/c4tc00234b