4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester
CAS No.:1392429-97-8
Molecular Formula:C₂₇H₃₅F₂N₅O₄S
Molecular Weight:563.669
Hs Code.:

Synonyms:4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester

There total 8 articles about 4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1392429-92-3
N-(2,4-difluoro-3-iodophenyl) propane-1-sulfonamide

: 1392429-88-7
tert-butyl 4-(methyl-(1H-pyrrolo[3,2-b]pyridin-5-yl)amino)piperidine-1-carboxylate

: 1392429-97-8
4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; caesium carbonate; In toluene; at 120 ℃;
DOI:10.1021/acs.jmedchem.9b02083

Reference yield:

: 1383745-37-6
N-(2,6-difluoro-3-(propylsulfonamido)phenyl)acetamide

: 1392429-97-8
4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / ethanol; water / 2 h / 80 °C

1.2: pH 6

2.1: sodium nitrite / trifluoroacetic acid / 0.5 h / 0 °C

2.2: 0.25 h

3.1: caesium carbonate; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane / copper(l) iodide / toluene / 40 h / 120 °C / Inert atmosphere

With hydrogenchloride; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; caesium carbonate; sodium nitrite; copper(l) iodide; In ethanol; water; toluene; trifluoroacetic acid; 3.1: Ullmann Reaction;

Reference yield:

: 147539-41-1
4-methylamino-piperidine-1-carboxylic acid tert-butyl ester

: 1392429-97-8
4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 30 h / 65 °C

2: N,N-dimethyl-formamide / 72 h / 90 °C / Inert atmosphere

3: hydrogen / palladium 10% on activated carbon / methanol / 1.5 h / 2585.81 Torr / Autoclave

4: caesium carbonate; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane / copper(l) iodide / toluene / 40 h / 120 °C / Inert atmosphere

With (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; copper(l) iodide; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide; toluene; acetonitrile; 4: Ullmann Reaction;