Technology Process of 2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-3-yl)propanoic acid
There total 12 articles about 2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-3-yl)propanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-3-yl)propanenitrile;
With
water; sodium hydroxide;
In
ethanol;
at 95 ℃;
for 16h;
With
hydrogenchloride;
In
ethanol; water;
pH=6 - 7;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: thionyl chloride / dichloromethane / 2 h / 20 °C
2.1: N,N-dimethyl-formamide / 16 h / 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C
3.2: 4 h / 20 °C
4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 0.75 h / 120 °C / Inert atmosphere; Microwave irradiation
5.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane; water / 16 h / 95 °C / Inert atmosphere
5.2: 16 h
6.1: sodium hydroxide; water / ethanol / 16 h / 95 °C
6.2: pH 6 - 7
With
thionyl chloride; water; potassium acetate; sodium hydride; potassium carbonate; sodium hydroxide;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 40 h / Reflux
2.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 105 °C
3.1: triethylamine / tetrahydrofuran / 14 h / 20 °C
4.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane; water / 16 h / 95 °C / Inert atmosphere
4.2: 16 h
5.1: sodium hydroxide; water / ethanol / 16 h / 95 °C
5.2: pH 6 - 7
With
water; sodium hydrogencarbonate; potassium carbonate; N,N-dimethyl-aniline; triethylamine; sodium hydroxide; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water;
