2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-3-yl)propanenitrile

Base Information

Chemical Name:2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-3-yl)propanenitrile
CAS No.:1272357-13-7
Molecular Formula:C₂₈H₂₂N₆
Molecular Weight:442.523
Hs Code.:

Synonyms:2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-3-yl)propanenitrile

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Chemical Property of 2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-3-yl)propanenitrile

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Technology Process of 2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-3-yl)propanenitrile

There total 10 articles about 2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-3-yl)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1272357-12-6
2-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)propanenitrile

: 1272353-93-1
2-chloro-5-phenyl-N-(pyridin-2-ylmethyl)quinazolin-4-amine

: 1272357-13-7
2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-3-yl)propanenitrile

Guidance literature:: 2-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)propanenitrile; 2-chloro-5-phenyl-N-(pyridin-2-ylmethyl)quinazolin-4-amine; With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 95 ℃; for 16h; Inert atmosphere;

for 16h;

Reference yield:

: 37669-64-0
(5-bromopyridin-3-yl)methanol

: 1272357-13-7
2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-3-yl)propanenitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / dichloromethane / 2 h / 20 °C

2.1: N,N-dimethyl-formamide / 16 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 4 h / 20 °C

4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.75 h / 120 °C / Inert atmosphere; Microwave irradiation

5.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 95 °C / Inert atmosphere

5.2: 16 h

With thionyl chloride; potassium acetate; sodium hydride; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 959237-01-5
5-bromoquinazoline-2,4(1H,3H)-dione

: 1272357-13-7
2-(5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridin-3-yl)propanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 40 h / Reflux

2.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 105 °C

3.1: triethylamine / tetrahydrofuran / 14 h / 20 °C

4.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 95 °C / Inert atmosphere

4.2: 16 h

With sodium hydrogencarbonate; potassium carbonate; N,N-dimethyl-aniline; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water;