3-Bromo-5-(chloromethyl)pyridine

Base Information

Chemical Name:3-Bromo-5-(chloromethyl)pyridine
CAS No.:120277-69-2
Molecular Formula:C6H5 Br Cl N
Molecular Weight:206.469
Hs Code.:
DSSTox Substance ID:DTXSID80470808
Wikidata:Q72453048
Mol file:120277-69-2.mol

Synonyms:3-bromo-5-(chloromethyl)pyridine;120277-69-2;MFCD10697600;PYRIDINE, 3-BROMO-5-(CHLOROMETHYL)-;5-bromonicotinyl chloride;SCHEMBL1502528;3-bromo-5-chloromethyl-pyridine;DTXSID80470808;NLPHAZLCNNDGPS-UHFFFAOYSA-N;3-Bromo-5-(chloromethyl)-pyridine;AKOS009292614;AB60029;AS-60861;SY021902;FT-0687469;EN300-37223;J-511966

Suppliers and Price of 3-Bromo-5-(chloromethyl)pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-Bromo-5-(chloromethyl)pyridine
100mg
$ 55.00

TRC
3-Bromo-5-(chloromethyl)pyridine
500mg
$ 170.00

Matrix Scientific
3-Bromo-5-(chloromethyl)pyridine hydrochloride 97%
1g
$ 341.00

Labseeker
3-bromo-5-(chloromethyl)pyridine 95
50g
$ 3630.00

Crysdot
3-Bromo-5-(chloromethyl)pyridine 95+%
1g
$ 280.00

Crysdot
3-Bromo-5-(chloromethyl)pyridine 95+%
5g
$ 603.00

Chemenu
3-Bromo-5-(chloromethyl)pyridine 95%
5g
$ 640.00

Biosynth Carbosynth
3-Bromo-5-(chloromethyl)pyridine
2 g
$ 592.00

Biosynth Carbosynth
3-Bromo-5-(chloromethyl)pyridine
1 g
$ 370.00

Biosynth Carbosynth
3-Bromo-5-(chloromethyl)pyridine
5 g
$ 1025.00

Total 23 raw suppliers

Chemical Property of 3-Bromo-5-(chloromethyl)pyridine

Chemical Property:

Vapor Pressure:0.015mmHg at 25°C
Refractive Index:1.575
Boiling Point:264.965ºC at 760 mmHg
PKA:2.10±0.20(Predicted)
Flash Point:114.047ºC
PSA：12.89000
Density:1.632g/cm3
LogP:3.38490
Storage Temp.:Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
XLogP3:1.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:204.92939
Heavy Atom Count:9
Complexity:89.1

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-5-(chloromethyl)pyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s): C
Hazard Codes:C
Statements: 20/21/22-34
Safety Statements: 22-26-36/37/39-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C=NC=C1Br)CCl

Technology Process of 3-Bromo-5-(chloromethyl)pyridine

There total 3 articles about 3-Bromo-5-(chloromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 37669-64-0
(5-bromopyridin-3-yl)methanol

: 120277-69-2
5-bromo-pyridin-3-ylmethyl chloride

Guidance literature:: With thionyl chloride; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 20826-04-4
5-bromo-3-pyridinecarboxylic acid

: 120277-69-2
5-bromo-pyridin-3-ylmethyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 0 - 20 °C

2.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 3 h / 20 °C / Cooling with ice

With thionyl chloride; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm201657x

Reference yield:

: 113118-81-3
5-bromopyridine-3-carbaldehyde

: 120277-69-2
5-bromo-pyridin-3-ylmethyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 1 h / 0 °C

2: thionyl chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; thionyl chloride; In methanol; dichloromethane;