Tetramisole hydrochloride

Base Information

• Chemical Name: Tetramisole hydrochloride
• CAS No.: 5086-74-8
• Molecular Formula: C11H12N2S^.HCl
• Molecular Weight: 240.757
• Hs Code.: 29349990
• European Community (EC) Number: 225-799-5
• NSC Number: 759175,758437,215179,170985
• UNII: 0NDK265MCV
• DSSTox Substance ID: DTXSID101017245
• Wikidata: Q27108410
• NCI Thesaurus Code: C152578
• ChEMBL ID: CHEMBL554891
• Mol file: 5086-74-8.mol

Synonyms:Nilverm;Tetramisole

Chemical Property of Tetramisole hydrochloride

Chemical Property:

• Appearance/Colour: white to pale cream crystalline powder
• Melting Point: 266-267 °C(lit.)
• Boiling Point: 344.4 °C at 760 mmHg
• Flash Point: 162.1 °C
• PSA: 40.90000
• LogP: 2.32160
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: Methanol (Slightly), Water (Slightly, Heated)
• Water Solubility.: 200 g/L (20 ºC)
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 240.0487973
• Heavy Atom Count: 15
• Complexity: 246

Purity/Quality:

99.5% ^*data from raw suppliers

Tetramisole hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38-20/21/22
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CSC2=NC(CN21)C3=CC=CC=C3.Cl
• Uses: Tetramisole hydrochloride is an inhibitor of alkaline phosphatases, is a high purity antiparasitic. It is suitable for inhibition of various alkaline phosphatase (i.e., liver, kidney, placenta, bone and tumor)(Intestinal alkaline phosphatases are only slightly inhibited.). Tetramisole has biological response modifier with anthelmintic activity. Anthelmintic (nematodes); immunomodulator.

Technology Process of Tetramisole hydrochloride

There total 10 articles about Tetramisole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

→ tetramisole hydrochloride (5086-74-8,74191-78-9)

Guidance literature:

Reference yield:

→ tetramisole hydrochloride (5086-74-8,74191-78-9) + Tetramisole (5036-02-2)

Guidance literature:

Reference yield:

phosphorous pentasulfide + 1-(2-hydroxy-ethyl)-4-phenyl-imidazolidin-2-one (65329-72-8) → tetramisole hydrochloride (5086-74-8,74191-78-9)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In ethanol; chloroform; toluene;

upstream raw materials:

pyrographite

1-(2-acetoxy-ethyl)-4-phenyl-imidazolidin-2-one

1-(2-methoxy-ethyl)-4-phenyl-imidazolidin-2-one

1-(2-hydroxy-ethyl)-4-phenyl-imidazolidin-2-one

Downstream raw materials:

2-Imino-3-styryl-thiazolidin

Tetramisole

R-(+)-6-phenyl-2,3,5,6-tetrahydro-imidazo<2,1b>thiazole

C₂₂H₂₄N₆O₄S₂

Refernces

• 1、 -. "Method for racemissing d (or l) tetramisole, and the relative product". . . Retrieved 2008/06/13.
• 2、 -. "Manufacture of tetramisole". . . Retrieved 2008/06/13.