[4-Benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-iodo-phenoxy]-acetonitrile

Base Information

Chemical Name:[4-Benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-iodo-phenoxy]-acetonitrile
CAS No.:195601-69-5
Molecular Formula:C₃₂H₃₂INO₃Si
Molecular Weight:633.601
Hs Code.:

Synonyms:[4-Benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-iodo-phenoxy]-acetonitrile

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Chemical Property of [4-Benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-iodo-phenoxy]-acetonitrile

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Technology Process of [4-Benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-iodo-phenoxy]-acetonitrile

There total 7 articles about [4-Benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-iodo-phenoxy]-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 100-39-0
benzyl bromide

: 195601-68-4
[2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-5-iodo-phenoxy]-acetonitrile

: 195601-69-5
[4-Benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-iodo-phenoxy]-acetonitrile

Guidance literature:: With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium hydride; In tetrahydrofuran; for 2.5h; Ambient temperature;
DOI:10.1021/jm970251r

Reference yield:

: 1194-98-5
2,5-Dihydroxybenzaldehyde

: 195601-69-5
[4-Benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-iodo-phenoxy]-acetonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / Et₃N / CH₂Cl₂ / Ambient temperature

2: 74 percent / K₂CO₃ / acetonitrile / 10 h / 80 °C

3: 93 percent / NaBH₄ / tetrahydrofuran; bis-(2-methoxy-ethyl) ether / 5 h

4: imidazole, 4-(dimethylamino)pyridine (DMAP) / CH₂Cl₂ / 1 h

5: NaOMe, MeOH / tetrahydrofuran / 2 h

6: 84 percent / morpholine, I₂ / CH₂Cl₂ / 1.5 h / Ambient temperature

7: 97 percent / NaH, DMPU / tetrahydrofuran / 2.5 h / Ambient temperature

With morpholine; 1H-imidazole; methanol; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium tetrahydroborate; iodine; sodium methylate; sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; diethylene glycol dimethyl ether; acetonitrile;
DOI:10.1021/jm970251r

Reference yield:

: 147067-92-3
2-hydroxy-5-benzoyloxybenzaldehyde

: 195601-69-5
[4-Benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-iodo-phenoxy]-acetonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / K₂CO₃ / acetonitrile / 10 h / 80 °C

2: 93 percent / NaBH₄ / tetrahydrofuran; bis-(2-methoxy-ethyl) ether / 5 h

3: imidazole, 4-(dimethylamino)pyridine (DMAP) / CH₂Cl₂ / 1 h

4: NaOMe, MeOH / tetrahydrofuran / 2 h

5: 84 percent / morpholine, I₂ / CH₂Cl₂ / 1.5 h / Ambient temperature

6: 97 percent / NaH, DMPU / tetrahydrofuran / 2.5 h / Ambient temperature

With morpholine; 1H-imidazole; methanol; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium tetrahydroborate; iodine; sodium methylate; sodium hydride; potassium carbonate; In tetrahydrofuran; dichloromethane; diethylene glycol dimethyl ether; acetonitrile;
DOI:10.1021/jm970251r