2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-({[1-methyl-4-oxo-5-(5-pyrimidinylmethyl)-1,4-dihydro-2-pyrimidinyl]thio}methyl)benzonitrile

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Chemical Name:2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-({[1-methyl-4-oxo-5-(5-pyrimidinylmethyl)-1,4-dihydro-2-pyrimidinyl]thio}methyl)benzonitrile
CAS No.:1380427-67-7
Molecular Formula:C₂₅H₁₇ClF₃N₅O₂S
Molecular Weight:543.956
Hs Code.:

Synonyms:2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-({[1-methyl-4-oxo-5-(5-pyrimidinylmethyl)-1,4-dihydro-2-pyrimidinyl]thio}methyl)benzonitrile

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Chemical Property of 2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-({[1-methyl-4-oxo-5-(5-pyrimidinylmethyl)-1,4-dihydro-2-pyrimidinyl]thio}methyl)benzonitrile

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Technology Process of 2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-({[1-methyl-4-oxo-5-(5-pyrimidinylmethyl)-1,4-dihydro-2-pyrimidinyl]thio}methyl)benzonitrile

There total 4 articles about 2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-({[1-methyl-4-oxo-5-(5-pyrimidinylmethyl)-1,4-dihydro-2-pyrimidinyl]thio}methyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380427-66-6
2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-({[4-oxo-5-(5-pyrimidinylmethyl)-1,4-dihydro-2-pyrimidinyl]thio}methyl)benzonitrile

: 74-88-4
methyl iodide

: 1380427-67-7
2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-({[1-methyl-4-oxo-5-(5-pyrimidinylmethyl)-1,4-dihydro-2-pyrimidinyl]thio}methyl)benzonitrile

Guidance literature:: 2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-({[4-oxo-5-(5-pyrimidinylmethyl)-1,4-dihydro-2-pyrimidinyl]thio}methyl)benzonitrile; With N-ethyl-N,N-diisopropylamine; zinc dibromide; In 1-methyl-pyrrolidin-2-one; acetonitrile; at 60 ℃; for 0.166667h;

methyl iodide; In 1-methyl-pyrrolidin-2-one; acetone; at 60 ℃; for 1.5h;

Reference yield:

: 218301-22-5
2-fluoro-5-formylbenzonitrile

: 1380427-67-7
2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-({[1-methyl-4-oxo-5-(5-pyrimidinylmethyl)-1,4-dihydro-2-pyrimidinyl]thio}methyl)benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 130 °C / Microwave irradiation

2.1: sodium tetrahydroborate; ethanol / 1.5 h / 20 °C / Inert atmosphere

3.1: thionyl chloride / dichloromethane / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 60 °C

5.1: N-ethyl-N,N-diisopropylamine; zinc dibromide / 1-methyl-pyrrolidin-2-one; acetonitrile / 0.17 h / 60 °C

5.2: 1.5 h / 60 °C

With sodium tetrahydroborate; thionyl chloride; ethanol; potassium carbonate; N-ethyl-N,N-diisopropylamine; zinc dibromide; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 6294-93-5
4-chloro-3-trifluoromethylphenol

: 1380427-67-7
2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-({[1-methyl-4-oxo-5-(5-pyrimidinylmethyl)-1,4-dihydro-2-pyrimidinyl]thio}methyl)benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 130 °C / Microwave irradiation

2.1: sodium tetrahydroborate; ethanol / 1.5 h / 20 °C / Inert atmosphere

3.1: thionyl chloride / dichloromethane / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 60 °C

5.1: N-ethyl-N,N-diisopropylamine; zinc dibromide / 1-methyl-pyrrolidin-2-one; acetonitrile / 0.17 h / 60 °C

5.2: 1.5 h / 60 °C

With sodium tetrahydroborate; thionyl chloride; ethanol; potassium carbonate; N-ethyl-N,N-diisopropylamine; zinc dibromide; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; acetonitrile;