N-[1-(3-isopropoxy-benzoyl)-6,7-dimethoxy-isoquinolin-4-yl]-acetamide

Base Information

Chemical Name:N-[1-(3-isopropoxy-benzoyl)-6,7-dimethoxy-isoquinolin-4-yl]-acetamide
CAS No.:798563-28-7
Molecular Formula:C₂₃H₂₄N₂O₅
Molecular Weight:408.454
Hs Code.:

Synonyms:N-[1-(3-isopropoxy-benzoyl)-6,7-dimethoxy-isoquinolin-4-yl]-acetamide

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Chemical Property of N-[1-(3-isopropoxy-benzoyl)-6,7-dimethoxy-isoquinolin-4-yl]-acetamide

Chemical Property:

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Technology Process of N-[1-(3-isopropoxy-benzoyl)-6,7-dimethoxy-isoquinolin-4-yl]-acetamide

There total 10 articles about N-[1-(3-isopropoxy-benzoyl)-6,7-dimethoxy-isoquinolin-4-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 798563-27-6
1-(3-isopropoxybenzoyl)-4-amino-6,7-dimethoxyisoquinoline hydrochloride

: 75-36-5
acetyl chloride

: 798563-28-7
N-[1-(3-isopropoxy-benzoyl)-6,7-dimethoxy-isoquinolin-4-yl]-acetamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃;

Reference yield:

: 93-17-4
3,4-dimethoxyphenylacetonitrile

: 798563-28-7
N-[1-(3-isopropoxy-benzoyl)-6,7-dimethoxy-isoquinolin-4-yl]-acetamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: ethanol; sodium / toluene / 2 h / 80 - 85 °C

1.2: 2 h / 80 °C

2.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 2844.39 Torr

3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 20 °C

4.1: phosphorus pentachloride / dichloromethane / 0 - 20 °C

5.1: sulfur / 0.33 h / 165 °C

6.1: selenium(IV) oxide / ethyl acetate / 0.5 h / Heating / reflux

7.1: sodium hydroxide; water / methanol / 1 h / Heating / reflux

8.1: diphenyl phosphoryl azide; triethylamine / tert-butyl alcohol / 3 h / Heating / reflux

8.2: 1 h / 20 °C

9.1: pyridine / dichloromethane / 20 °C

With pyridine; hydrogenchloride; sodium hydroxide; selenium(IV) oxide; ethanol; phosphorus pentachloride; diphenyl phosphoryl azide; water; hydrogen; sodium; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sulfur; triethylamine; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; water; ethyl acetate; toluene; tert-butyl alcohol;

Reference yield:

: 36848-69-8
ethyl 2-cyano-2-(3,4-dimethoxyphenyl)acetate

: 798563-28-7
N-[1-(3-isopropoxy-benzoyl)-6,7-dimethoxy-isoquinolin-4-yl]-acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 2844.39 Torr

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 20 °C

3.1: phosphorus pentachloride / dichloromethane / 0 - 20 °C

4.1: sulfur / 0.33 h / 165 °C

5.1: selenium(IV) oxide / ethyl acetate / 0.5 h / Heating / reflux

6.1: sodium hydroxide; water / methanol / 1 h / Heating / reflux

7.1: diphenyl phosphoryl azide; triethylamine / tert-butyl alcohol / 3 h / Heating / reflux

7.2: 1 h / 20 °C

8.1: pyridine / dichloromethane / 20 °C

With pyridine; hydrogenchloride; sodium hydroxide; selenium(IV) oxide; phosphorus pentachloride; diphenyl phosphoryl azide; water; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sulfur; triethylamine; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; water; ethyl acetate; tert-butyl alcohol;