3-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester

Base Information

Chemical Name:3-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester
CAS No.:1455094-75-3
Molecular Formula:C₂₄H₂₃N₃O₆
Molecular Weight:449.463
Hs Code.:

Synonyms:3-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester

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Chemical Property of 3-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester

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Technology Process of 3-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester

There total 11 articles about 3-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1455094-73-1
3-[(4-hydroxy-1-iodo-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester

: copper(l) cyanide

: 1455094-75-3
3-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester

Guidance literature:: In N,N-dimethyl-formamide; at 160 ℃; for 0.1h; Inert atmosphere;

Reference yield:

: 1455091-04-9
2-(chloromethyl)-4-phenoxybenzoic acid methyl ester

: 1455094-75-3
3-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 50 °C

2: sodium methylate / dimethyl sulfoxide; methanol / 0.5 h / 20 °C

3: ethanol / 18 h / Reflux

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C

5: bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate / dichloromethane / 20 h / 20 °C

6: N,N-dimethyl-formamide / 0.1 h / 160 °C / Inert atmosphere

With sodium methylate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium iodide; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; In methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1572-98-1
2-cyano-2-methyl-propionic acid ethyl ester

: 1455094-75-3
3-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / ethanol / 20 h / 20 °C

2: ethanol / 18 h / Reflux

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C

4: bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate / dichloromethane / 20 h / 20 °C

5: N,N-dimethyl-formamide / 0.1 h / 160 °C / Inert atmosphere

With hydrogen; 3-chloro-benzenecarboperoxoic acid; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; In ethanol; dichloromethane; N,N-dimethyl-formamide;