3-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid

Base Information

• Chemical Name: 3-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid
• CAS No.: 1455090-30-8
• Molecular Formula: C₂₂H₁₉N₃O₆
• Molecular Weight: 421.409
• Mol file: 1455090-30-8.mol

Synonyms:3-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid

Chemical Property of 3-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid

There total 12 articles about 3-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester (1455094-75-3) → 3-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid (1455090-30-8)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; ethanol; water; at 20 ℃; for 18h;

Reference yield:

2-(chloromethyl)-4-phenoxybenzoic acid methyl ester (1455091-04-9) → 3-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid (1455090-30-8)

Guidance literature:

Multi-step reaction with 7 steps

1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 50 °C

2: sodium methylate / dimethyl sulfoxide; methanol / 0.5 h / 20 °C

3: ethanol / 18 h / Reflux

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C

5: bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate / dichloromethane / 20 h / 20 °C

6: N,N-dimethyl-formamide / 0.1 h / 160 °C / Inert atmosphere

7: sodium hydroxide / tetrahydrofuran; water; ethanol / 18 h / 20 °C

With sodium methylate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium iodide; sodium hydroxide; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

2-cyano-2-methyl-propionic acid ethyl ester (1572-98-1) → 3-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid (1455090-30-8)

Guidance literature:

Multi-step reaction with 6 steps

1: hydrogen / ethanol / 20 h / 20 °C

2: ethanol / 18 h / Reflux

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C

4: bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate / dichloromethane / 20 h / 20 °C

5: N,N-dimethyl-formamide / 0.1 h / 160 °C / Inert atmosphere

6: sodium hydroxide / tetrahydrofuran; water; ethanol / 18 h / 20 °C

With hydrogen; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

2-(chloromethyl)-4-phenoxybenzoic acid methyl ester

2-cyano-2-methyl-propionic acid ethyl ester

3-amino-2,2-dimethylpropionic acid ethyl ester

2-{[(methoxycarbonylmethyl)(toluene-4-sulfonyl)amino]methyl}-4-phenoxybenzoic acid methyl ester

Refernces