Technology Process of methyl 1,3-dihydro-1-oxo-4-isobenzofuranacetate
There total 8 articles about methyl 1,3-dihydro-1-oxo-4-isobenzofuranacetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: SOCl2 / 2 h / Heating
2: 2) Ag2O / 1) THF, Et2O, RT, 30 min, 2) 50 min, reflux
With
thionyl chloride; silver(l) oxide;
DOI:10.1055/s-1990-26963
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 78 percent / N-methylpyrrolidinone / 18 h / Heating
2: 1) 20percent aq. KOH, 2) conc. HCl / 1) 5h, reflux
3: SOCl2 / 1 h / Heating
4: 1) Br2 / 1) 180 - 185 deg C, 15 min, 2) 0 deg C, 30 min
5: 1) aq. KOH, 2) conc. HCl / 1) 45 min
6: SOCl2 / 2 h / Heating
7: 2) Ag2O / 1) THF, Et2O, RT, 30 min, 2) 50 min, reflux
With
1-methyl-pyrrolidin-2-one; hydrogenchloride; potassium hydroxide; thionyl chloride; bromine; silver(l) oxide;
DOI:10.1055/s-1990-26963
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1) 20percent aq. KOH, 2) conc. HCl / 1) 5h, reflux
2: SOCl2 / 1 h / Heating
3: 1) Br2 / 1) 180 - 185 deg C, 15 min, 2) 0 deg C, 30 min
4: 1) aq. KOH, 2) conc. HCl / 1) 45 min
5: SOCl2 / 2 h / Heating
6: 2) Ag2O / 1) THF, Et2O, RT, 30 min, 2) 50 min, reflux
With
hydrogenchloride; potassium hydroxide; thionyl chloride; bromine; silver(l) oxide;
DOI:10.1055/s-1990-26963
