Technology Process of 4-(3-amino-4-methoxyphenyl)-5,6,7-trimethoxycoumarin
There total 8 articles about 4-(3-amino-4-methoxyphenyl)-5,6,7-trimethoxycoumarin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-(3-tert-butoxycarbonylamino-4-methoxyphenyl)-5,6,7-trimethoxycoumarin;
With
hydrogenchloride; ethanol;
In
ethyl acetate;
at 50 ℃;
With
sodium hydroxide;
In
water; ethyl acetate;
at 20 ℃;
for 0.5h;
DOI:10.1007/s11172-013-0149-3
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium carbonate; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / toluene / 17 h / 20 - 110 °C / Inert atmosphere
2.1: hydrogenchloride; ethanol / ethyl acetate / 50 °C
2.2: 0.5 h / 20 °C
With
hydrogenchloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); ethanol; potassium carbonate;
In
ethyl acetate; toluene;
1.1: |Suzuki-Miyaura Coupling;
DOI:10.1007/s11172-013-0149-3
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tin(II) chloride hydrate / ethanol; ethyl acetate / 0.5 h / 70 °C
2.1: ethanol / 36 h / 20 °C
3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere
4.1: potassium carbonate; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / toluene / 17 h / 20 - 110 °C / Inert atmosphere
5.1: hydrogenchloride; ethanol / ethyl acetate / 50 °C
5.2: 0.5 h / 20 °C
With
hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); tin(II) chloride hydrate; ethanol; potassium acetate; potassium carbonate;
In
ethanol; dimethyl sulfoxide; ethyl acetate; toluene;
4.1: |Suzuki-Miyaura Coupling;
DOI:10.1007/s11172-013-0149-3
