4-(benzyloxy)-2-(methylamino)-6-(2-(trimethylsilyl)ethylamino)pyrimidine-5-carbaldehyde

Base Information

Chemical Name:4-(benzyloxy)-2-(methylamino)-6-(2-(trimethylsilyl)ethylamino)pyrimidine-5-carbaldehyde
CAS No.:1268383-12-5
Molecular Formula:C₁₈H₂₆N₄O₂Si
Molecular Weight:358.516
Hs Code.:

Synonyms:4-(benzyloxy)-2-(methylamino)-6-(2-(trimethylsilyl)ethylamino)pyrimidine-5-carbaldehyde

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Chemical Property of 4-(benzyloxy)-2-(methylamino)-6-(2-(trimethylsilyl)ethylamino)pyrimidine-5-carbaldehyde

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Technology Process of 4-(benzyloxy)-2-(methylamino)-6-(2-(trimethylsilyl)ethylamino)pyrimidine-5-carbaldehyde

There total 4 articles about 4-(benzyloxy)-2-(methylamino)-6-(2-(trimethylsilyl)ethylamino)pyrimidine-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1268383-11-4
4-Chloro-2-(methylamino)-6-(2-(trimethylsilyl)ethylamino)pyrimidine-5-carbaldehyde

: 100-51-6,185532-71-2
benzyl alcohol

: 1268383-12-5
4-(benzyloxy)-2-(methylamino)-6-(2-(trimethylsilyl)ethylamino)pyrimidine-5-carbaldehyde

Guidance literature:: benzyl alcohol; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.25h; Inert atmosphere;

4-Chloro-2-(methylamino)-6-(2-(trimethylsilyl)ethylamino)pyrimidine-5-carbaldehyde; In tetrahydrofuran; for 24h; Inert atmosphere; Reflux;
DOI:10.1016/j.tetlet.2010.11.122

Reference yield:

: 1268383-10-3
2,4-dichloro-6-(2-(trimethylsilyl)ethylamino)pyrimidine-5-carbaldehyde

: 1268383-12-5
4-(benzyloxy)-2-(methylamino)-6-(2-(trimethylsilyl)ethylamino)pyrimidine-5-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

2.2: 24 h / Inert atmosphere; Reflux

With sodium hydride; In tetrahydrofuran;
DOI:10.1016/j.tetlet.2010.11.122

Reference yield:

: 50270-27-4
2,4,6-trichloropyrimidine-5-carbaldehyde

: 1268383-12-5
4-(benzyloxy)-2-(methylamino)-6-(2-(trimethylsilyl)ethylamino)pyrimidine-5-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / -78 - 20 °C / Inert atmosphere

2.1: tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

3.2: 24 h / Inert atmosphere; Reflux

With sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2010.11.122