1-methoxy-4-((((1R,2R)-2-(oct-2-yn-1-yl)cyclopent-3-en-1-yl)oxy)methyl)benzene

Base Information

Chemical Name:1-methoxy-4-((((1R,2R)-2-(oct-2-yn-1-yl)cyclopent-3-en-1-yl)oxy)methyl)benzene
CAS No.:1605291-82-4
Molecular Formula:C₂₁H₂₈O₂
Molecular Weight:312.452
Hs Code.:

Synonyms:1-methoxy-4-((((1R,2R)-2-(oct-2-yn-1-yl)cyclopent-3-en-1-yl)oxy)methyl)benzene

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Chemical Property of 1-methoxy-4-((((1R,2R)-2-(oct-2-yn-1-yl)cyclopent-3-en-1-yl)oxy)methyl)benzene

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Technology Process of 1-methoxy-4-((((1R,2R)-2-(oct-2-yn-1-yl)cyclopent-3-en-1-yl)oxy)methyl)benzene

There total 4 articles about 1-methoxy-4-((((1R,2R)-2-(oct-2-yn-1-yl)cyclopent-3-en-1-yl)oxy)methyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 628-17-1
amyl iodide

: 1605291-81-3
1-methoxy-4-((((1R,2R)-2-(prop-2-yn-1-yl)cyclopent-3-en-1-yl)oxy)methyl)benzene

: 1605291-82-4
1-methoxy-4-((((1R,2R)-2-(oct-2-yn-1-yl)cyclopent-3-en-1-yl)oxy)methyl)benzene

Guidance literature:: 1-methoxy-4-((((1R,2R)-2-(prop-2-yn-1-yl)cyclopent-3-en-1-yl)oxy)methyl)benzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

amyl iodide; With N,N,N,N,N,N-hexamethylphosphoric triamide; In tetrahydrofuran; at -78 - 20 ℃; for 2h;
DOI:10.1021/ol500654g

Reference yield:

: 1605291-78-8
2-((1R,5R)-5-((4-methoxybenzyl)oxy)cyclopent-2-en-1-yl)-N,N-dimethylacetamide

: 1605291-82-4
1-methoxy-4-((((1R,2R)-2-(oct-2-yn-1-yl)cyclopent-3-en-1-yl)oxy)methyl)benzene

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 1 h / -105 °C

2.1: triphenylphosphine / dichloromethane / 0.17 h / 0 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

4.2: 2 h / -78 - 20 °C

With n-butyllithium; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; 2.1: |Corey-Fuchs Alkyne Synthesis;
DOI:10.1021/ol500654g

Reference yield:

: 1605291-79-9
2-((1R,5R)-5-((4-methoxybenzyl)oxy)cyclopent-2-en-1-yl)acetaldehyde

: 1605291-82-4
1-methoxy-4-((((1R,2R)-2-(oct-2-yn-1-yl)cyclopent-3-en-1-yl)oxy)methyl)benzene

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine / dichloromethane / 0.17 h / 0 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: 2 h / -78 - 20 °C

With n-butyllithium; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; 1.1: |Corey-Fuchs Alkyne Synthesis;
DOI:10.1021/ol500654g