methyl 5-bromo-2-(4-fluorophenyl)-6-(methanesulfonamido)benzofuran-3-carboxylate

Base Information

Chemical Name:methyl 5-bromo-2-(4-fluorophenyl)-6-(methanesulfonamido)benzofuran-3-carboxylate
CAS No.:1333225-34-5
Molecular Formula:C₁₇H₁₃BrFNO₅S
Molecular Weight:442.262
Hs Code.:

Synonyms:methyl 5-bromo-2-(4-fluorophenyl)-6-(methanesulfonamido)benzofuran-3-carboxylate

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Chemical Property of methyl 5-bromo-2-(4-fluorophenyl)-6-(methanesulfonamido)benzofuran-3-carboxylate

Chemical Property:

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Technology Process of methyl 5-bromo-2-(4-fluorophenyl)-6-(methanesulfonamido)benzofuran-3-carboxylate

There total 8 articles about methyl 5-bromo-2-(4-fluorophenyl)-6-(methanesulfonamido)benzofuran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1333225-33-4
methyl 6-amino-5-bromo-2-(4-fluorophenyl)benzofuran-3-carboxylate

: 124-63-0
methanesulfonyl chloride

: 1333225-34-5
methyl 5-bromo-2-(4-fluorophenyl)-6-(methanesulfonamido)benzofuran-3-carboxylate

Guidance literature:: With pyridine; In dichloromethane; at 30 ℃; for 22h; Inert atmosphere; Large scale;
DOI:10.1021/acs.oprd.5b00405

Reference yield:

: 1333225-31-2
methyl 5-bromo-2-(4-fluorophenyl)benzofuran-3-carboxylate

: 1333225-34-5
methyl 5-bromo-2-(4-fluorophenyl)-6-(methanesulfonamido)benzofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: nitric acid / chloroform / 4 h / 20 °C

2: ammonium chloride; iron / water; tetrahydrofuran; methanol / 3 h / Reflux

3: pyridine / dichloromethane / 15 h / 0 - 20 °C

With pyridine; nitric acid; iron; ammonium chloride; In tetrahydrofuran; methanol; dichloromethane; chloroform; water;

Reference yield:

: 1333225-32-3
methyl 5-bromo-2-(4-fluorophenyl)-6-nitrobenzofuran-3-carboxylate

: 1333225-34-5
methyl 5-bromo-2-(4-fluorophenyl)-6-(methanesulfonamido)benzofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium chloride; iron / water; tetrahydrofuran; methanol / 3 h / Reflux

2: pyridine / dichloromethane / 15 h / 0 - 20 °C

With pyridine; iron; ammonium chloride; In tetrahydrofuran; methanol; dichloromethane; water;