(4R,6S)-2,2-dimethyl-6-{2-[4-(phenylmethoxy)phenyl]ethyl}-1,3-dioxan-4-carboxaldehyde

Base Information

Chemical Name:(4R,6S)-2,2-dimethyl-6-{2-[4-(phenylmethoxy)phenyl]ethyl}-1,3-dioxan-4-carboxaldehyde
CAS No.:1428899-28-8
Molecular Formula:C₂₂H₂₆O₄
Molecular Weight:354.446
Hs Code.:

Synonyms:(4R,6S)-2,2-dimethyl-6-{2-[4-(phenylmethoxy)phenyl]ethyl}-1,3-dioxan-4-carboxaldehyde

Suppliers and Price of (4R,6S)-2,2-dimethyl-6-{2-[4-(phenylmethoxy)phenyl]ethyl}-1,3-dioxan-4-carboxaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4R,6S)-2,2-dimethyl-6-{2-[4-(phenylmethoxy)phenyl]ethyl}-1,3-dioxan-4-carboxaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4R,6S)-2,2-dimethyl-6-{2-[4-(phenylmethoxy)phenyl]ethyl}-1,3-dioxan-4-carboxaldehyde

There total 13 articles about (4R,6S)-2,2-dimethyl-6-{2-[4-(phenylmethoxy)phenyl]ethyl}-1,3-dioxan-4-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428899-25-5
(4R,6S)-2,2-dimethyl-6-{2-[4-(phenylmethoxy)phenyl]ethyl}-1,3-dioxan-4-methanol

: 1428899-28-8
(4R,6S)-2,2-dimethyl-6-{2-[4-(phenylmethoxy)phenyl]ethyl}-1,3-dioxan-4-carboxaldehyde

Guidance literature:: (4R,6S)-2,2-dimethyl-6-{2-[4-(phenylmethoxy)phenyl]ethyl}-1,3-dioxan-4-methanol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 1.5h;

With triethylamine; In dichloromethane; at 0 ℃;
DOI:10.1002/hlca.201200165

Reference yield:

: 68486-77-1
3-(4-(benzyloxy)phenyl)propanal

: 1428899-28-8
(4R,6S)-2,2-dimethyl-6-{2-[4-(phenylmethoxy)phenyl]ethyl}-1,3-dioxan-4-carboxaldehyde

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Reflux

3.1: titanium(IV) isopropylate; L-(+)-diisopropyl tartrate / dichloromethane / 0.5 h / -20 °C / Molecular sieve

3.2: 5 h / -20 °C

4.1: titanium(IV) isopropylate; D-(-)-diisopropyl tartrate / dichloromethane / 0.5 h / -20 °C / Molecular sieve

4.2: 6 h / -20 °C

5.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 2 h / 0 - 20 °C / Inert atmosphere

6.1: toluene-4-sulfonic acid / dichloromethane / 0.5 h / 20 °C

7.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 2 h / 20 °C

8.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 1.5 h / -78 °C

8.2: 0 °C

With titanium(IV) isopropylate; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; L-(+)-diisopropyl tartrate; D-(-)-diisopropyl tartrate; toluene-4-sulfonic acid; dimethyl sulfoxide; sodium bis(2-methoxyethoxy)aluminium dihydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; hexane; dichloromethane; water; toluene; 3.1: |Sharpless Asymmetric Epoxidation / 3.2: |Sharpless Asymmetric Epoxidation / 4.1: |Sharpless Asymmetric Epoxidation / 4.2: |Sharpless Asymmetric Epoxidation / 8.1: |Swern Oxidation / 8.2: |Swern Oxidation;
DOI:10.1002/hlca.201200165

Reference yield:

: 1428899-15-3
6-[(4-methoxyphenyl)methoxy]-1-[4-(phenylmethoxy)phenyl]hex-4-en-3-ol

: 1428899-28-8
(4R,6S)-2,2-dimethyl-6-{2-[4-(phenylmethoxy)phenyl]ethyl}-1,3-dioxan-4-carboxaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1.1: titanium(IV) isopropylate; L-(+)-diisopropyl tartrate / dichloromethane / 0.5 h / -20 °C / Molecular sieve

1.2: 5 h / -20 °C

2.1: titanium(IV) isopropylate; D-(-)-diisopropyl tartrate / dichloromethane / 0.5 h / -20 °C / Molecular sieve

2.2: 6 h / -20 °C

3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 2 h / 0 - 20 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / dichloromethane / 0.5 h / 20 °C

5.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 2 h / 20 °C

6.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 1.5 h / -78 °C

6.2: 0 °C

With titanium(IV) isopropylate; oxalyl dichloride; L-(+)-diisopropyl tartrate; D-(-)-diisopropyl tartrate; toluene-4-sulfonic acid; dimethyl sulfoxide; sodium bis(2-methoxyethoxy)aluminium dihydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; water; toluene; 1.1: |Sharpless Asymmetric Epoxidation / 1.2: |Sharpless Asymmetric Epoxidation / 2.1: |Sharpless Asymmetric Epoxidation / 2.2: |Sharpless Asymmetric Epoxidation / 6.1: |Swern Oxidation / 6.2: |Swern Oxidation;
DOI:10.1002/hlca.201200165