(1S,6R)-1-Cyano-3,4-dimethyl-6-phenyl-cyclohex-3-enecarboxylic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:(1S,6R)-1-Cyano-3,4-dimethyl-6-phenyl-cyclohex-3-enecarboxylic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester
CAS No.:144901-86-0
Molecular Formula:C₂₂H₂₅NO₄
Molecular Weight:367.445
Hs Code.:

Synonyms:(1S,6R)-1-Cyano-3,4-dimethyl-6-phenyl-cyclohex-3-enecarboxylic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

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Chemical Property of (1S,6R)-1-Cyano-3,4-dimethyl-6-phenyl-cyclohex-3-enecarboxylic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

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Technology Process of (1S,6R)-1-Cyano-3,4-dimethyl-6-phenyl-cyclohex-3-enecarboxylic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

There total 3 articles about (1S,6R)-1-Cyano-3,4-dimethyl-6-phenyl-cyclohex-3-enecarboxylic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 142635-87-8
(E)-2-cyanocinnamate of (R)-pantolactone

: 513-81-5
2,3-dimethyl-buta-1,3-diene

: 144901-86-0
(1S,6R)-1-Cyano-3,4-dimethyl-6-phenyl-cyclohex-3-enecarboxylic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

: 144846-58-2
(1R,6S)-1-cyano-3,4-dimethyl-6-phenyl-3-cyclohexen-1-carboxylate of (R)-pantolactone

Guidance literature:: With titanium tetrachloride; In dichloromethane; at -40 ℃; for 24h;
DOI:10.1016/S0957-4166(00)82189-8

Reference yield:

: 14378-06-4
(E)-α-cyanocinnamic acid

: 144901-86-0
(1S,6R)-1-Cyano-3,4-dimethyl-6-phenyl-cyclohex-3-enecarboxylic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / N,N-dimethyl-4-aminopyridine, N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / a) 0 deg C, 1 h, 2.) RT, 20 h

2: TiCl₄ / CH₂Cl₂ / 24 h / -40 °C

With dmap; titanium tetrachloride; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1016/S0957-4166(00)82189-8

Reference yield:

: 599-04-2
(R)-Pantolacton

: 144901-86-0
(1S,6R)-1-Cyano-3,4-dimethyl-6-phenyl-cyclohex-3-enecarboxylic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / N,N-dimethyl-4-aminopyridine, N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / a) 0 deg C, 1 h, 2.) RT, 20 h

2: TiCl₄ / CH₂Cl₂ / 24 h / -40 °C

With dmap; titanium tetrachloride; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1016/S0957-4166(00)82189-8