2-(1-aza-2,2-dimethyl-3-oxa-5(S)-phenylcyclopentyl)-4-phenyl-(R)-butanoic acid tert-butyl ester

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Chemical Name:2-(1-aza-2,2-dimethyl-3-oxa-5(S)-phenylcyclopentyl)-4-phenyl-(R)-butanoic acid tert-butyl ester
CAS No.:124619-90-5
Molecular Formula:C₂₅H₃₃NO₃
Molecular Weight:395.542
Hs Code.:

Synonyms:2-(1-aza-2,2-dimethyl-3-oxa-5(S)-phenylcyclopentyl)-4-phenyl-(R)-butanoic acid tert-butyl ester

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Chemical Property of 2-(1-aza-2,2-dimethyl-3-oxa-5(S)-phenylcyclopentyl)-4-phenyl-(R)-butanoic acid tert-butyl ester

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Technology Process of 2-(1-aza-2,2-dimethyl-3-oxa-5(S)-phenylcyclopentyl)-4-phenyl-(R)-butanoic acid tert-butyl ester

There total 2 articles about 2-(1-aza-2,2-dimethyl-3-oxa-5(S)-phenylcyclopentyl)-4-phenyl-(R)-butanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 124685-70-7
pentacarbonyl{((5S)-1-aza-2,2-dimethyl-3-oxa-5-phenylcyclopentyl)(methyl)carbene}chromium⁽⁰⁾

: 100-39-0
benzyl bromide

: 75-65-0
tert-butyl alcohol

: 124619-90-5
2-(1-aza-2,2-dimethyl-3-oxa-5(S)-phenylcyclopentyl)-4-phenyl-(R)-butanoic acid tert-butyl ester

: 199620-14-9,13007-92-6
chromium⁽⁰⁾ hexacarbonyl

Guidance literature:: With n-butyllithium; carbon monoxide; In tetrahydrofuran; hexane; tert-butyl alcohol; Irradiation (UV/VIS); soln. of carbene in THF is cooled to -78°C, deoxygenated, kept under Ar; BuLi in hexane is added at -78°C, benzylbromide is added, stirring for 2 h; resulting intermediate is taken in t-BuOH, irradn. under 75 psi of CO for 15-24 h;; removing Cr(CO)6 by filtn.; filtrate is concd. in vacuo, dissolved in ether-hexane, photooxidized, filtn., evapn., radial chromy. yields amino ester, NMR, IR, elem. anal.;