5-(4-chlorobenzyloxymethyl)-4-(2-phenylbenzyl)-2,4-dihydro[1,2,4]triazole-3-thiol potassium salt

Base Information

• Chemical Name: 5-(4-chlorobenzyloxymethyl)-4-(2-phenylbenzyl)-2,4-dihydro[1,2,4]triazole-3-thiol potassium salt
• CAS No.: 1257330-47-4
• Molecular Formula: C₂₂H₁₇ClN₃OS*K
• Molecular Weight: 446.014
• Mol file: 1257330-47-4.mol

Synonyms:5-(4-chlorobenzyloxymethyl)-4-(2-phenylbenzyl)-2,4-dihydro[1,2,4]triazole-3-thiol potassium salt

Chemical Property of 5-(4-chlorobenzyloxymethyl)-4-(2-phenylbenzyl)-2,4-dihydro[1,2,4]triazole-3-thiol potassium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-chlorobenzyloxymethyl)-4-(2-phenylbenzyl)-2,4-dihydro[1,2,4]triazole-3-thiol potassium salt

There total 1 articles about 5-(4-chlorobenzyloxymethyl)-4-(2-phenylbenzyl)-2,4-dihydro[1,2,4]triazole-3-thiol potassium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-phenylbenzylamine (1924-77-2) + di-2-pyridyl thionocarbonate (96989-50-3) + (4-chlorophenoxy)acetic acid hydrazide (2381-75-1) → 5-(4-chlorobenzyloxymethyl)-4-(2-phenylbenzyl)-2,4-dihydro[1,2,4]triazole-3-thiol potassium salt (1257330-47-4)

Guidance literature:

2-phenylbenzylamine; di-2-pyridyl thionocarbonate; In N,N-dimethyl-formamide; at 55 ℃; for 1.5h;

(4-chlorophenoxy)acetic acid hydrazide; In N,N-dimethyl-formamide; at 55 ℃; for 1.5h;

With potassium hydroxide; In ethanol; water; at 85 ℃; for 5h;

DOI:10.1016/j.bmcl.2010.08.108

Reference yield: 100.0%

5-(4-chlorobenzyloxymethyl)-4-(2-phenylbenzyl)-2,4-dihydro[1,2,4]triazole-3-thiol potassium salt (1257330-47-4) + methyl iodide (74-88-4) → 5-(4-chlorobenzyloxymethyl)-4-(2-phenylbenzyl)-3-(methylmercapto)-4H-[1,2,4]triazole (1257330-62-3)

Guidance literature:

In methanol; for 18h;

DOI:10.1016/j.bmcl.2010.08.108

upstream raw materials:

2-phenylbenzylamine

di-2-pyridyl thionocarbonate

(4-chlorophenoxy)acetic acid hydrazide

Downstream raw materials:

5-(4-chlorobenzyloxymethyl)-4-(2-phenylbenzyl)-3-(methylmercapto)-4H-[1,2,4]triazole