Technology Process of (S)-1-(but-3-en-2-yl)-2,3-dimethoxy-4-methylbenzene
There total 9 articles about (S)-1-(but-3-en-2-yl)-2,3-dimethoxy-4-methylbenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
bi(allylnickel bromide); (R)-2,2'-binaphthoyl-benzyl-(S)-[1-(1-naphthylethyl)]aminoylphosphine; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate;
In
dichloromethane;
at -80 ℃;
for 2h;
under 760.051 Torr;
enantioselective reaction;
Inert atmosphere;
DOI:10.1021/ja201321v
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium / hexane; pentane / 16.5 h / 20 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: potassium hexamethylsilazane / tetrahydrofuran / Inert atmosphere
2.2: 16 h / Reflux; Inert atmosphere
3.1: bi(allylnickel bromide); (R)-2,2'-binaphthoyl-benzyl-(S)-[1-(1-naphthylethyl)]aminoylphosphine; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate / dichloromethane / 2 h / -80 °C / 760.05 Torr / Inert atmosphere
With
bi(allylnickel bromide); N,N,N,N,-tetramethylethylenediamine; (R)-2,2'-binaphthoyl-benzyl-(S)-[1-(1-naphthylethyl)]aminoylphosphine; tert.-butyl lithium; potassium hexamethylsilazane; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate;
In
tetrahydrofuran; hexane; dichloromethane; pentane;
DOI:10.1021/ja201321v
- Guidance literature:
-
ethene;
With
(3aR,8aR)-6-(2-(diphenylphosphanyl)-4,6-di-tert-pentylphenoxy)-2,2-dimethyl-4,4,8,8-tetraphenyltetrahydro[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine; diethylaluminium chloride; cobalt(II) chloride;
In
tetrahydrofuran; dichloromethane;
at -20 ℃;
for 0.0833333h;
Inert atmosphere;
Schlenk technique;
2,3-dimethoxy-1-methyl-4-vinylbenzene;
In
tetrahydrofuran; dichloromethane;
at -20 ℃;
for 6h;
Overall yield = 87 percent; Overall yield = 2.692 g;
Inert atmosphere;
Schlenk technique;
DOI:10.1002/chem.202101863
