4-(4-(2H-tetrazol-5-yl)phenyl)-6-(pyridin-3-yl)-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one

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Chemical Name:4-(4-(2H-tetrazol-5-yl)phenyl)-6-(pyridin-3-yl)-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one
CAS No.:1283119-62-9
Molecular Formula:C₂₀H₁₅N₇OS
Molecular Weight:401.451
Hs Code.:

Synonyms:4-(4-(2H-tetrazol-5-yl)phenyl)-6-(pyridin-3-yl)-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one

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Chemical Property of 4-(4-(2H-tetrazol-5-yl)phenyl)-6-(pyridin-3-yl)-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one

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Technology Process of 4-(4-(2H-tetrazol-5-yl)phenyl)-6-(pyridin-3-yl)-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one

There total 4 articles about 4-(4-(2H-tetrazol-5-yl)phenyl)-6-(pyridin-3-yl)-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1179511-06-8
1-(pyridin-3-yl)-2-(thiophen-3-yl)ethanone

: 57-13-6
urea

: 74815-22-8
4-(2H-tetrazol-5-yl)benzaldehyde

: 1283119-62-9
4-(4-(2H-tetrazol-5-yl)phenyl)-6-(pyridin-3-yl)-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one

Guidance literature:: With hydrogenchloride; In ethanol; water; Reflux; Inert atmosphere;

Reference yield:

: 59-67-6
nicotinic acid

: 1283119-62-9
4-(4-(2H-tetrazol-5-yl)phenyl)-6-(pyridin-3-yl)-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / tetrahydrofuran / 2 h / 80 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

2.2: 4 h / -78 °C

3.1: water; sodium chloride / dimethyl sulfoxide / 2 h / 160 °C

4.1: hydrogenchloride / ethanol; water / Reflux; Inert atmosphere

With hydrogenchloride; thionyl chloride; water; sodium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide;

Reference yield:

: 10400-19-8
3-pyridinecarbonyl chloride

: 1283119-62-9
4-(4-(2H-tetrazol-5-yl)phenyl)-6-(pyridin-3-yl)-5-(thiophen-3-yl)-3,4-dihydropyrimidin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

1.2: 4 h / -78 °C

2.1: water; sodium chloride / dimethyl sulfoxide / 2 h / 160 °C

3.1: hydrogenchloride / ethanol; water / Reflux; Inert atmosphere

With hydrogenchloride; water; sodium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide;