ethyl 5-(4-chlorophenyl)-2-methyl-4-(3-(4-(4-nitrophenyl)piperazin-1-yl)phenyl)-1-propyl-1H-pyrrole-3-carboxylate

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Chemical Name:ethyl 5-(4-chlorophenyl)-2-methyl-4-(3-(4-(4-nitrophenyl)piperazin-1-yl)phenyl)-1-propyl-1H-pyrrole-3-carboxylate
CAS No.:1402141-68-7
Molecular Formula:C₃₃H₃₅ClN₄O₄
Molecular Weight:587.118
Hs Code.:

Synonyms:ethyl 5-(4-chlorophenyl)-2-methyl-4-(3-(4-(4-nitrophenyl)piperazin-1-yl)phenyl)-1-propyl-1H-pyrrole-3-carboxylate

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Chemical Property of ethyl 5-(4-chlorophenyl)-2-methyl-4-(3-(4-(4-nitrophenyl)piperazin-1-yl)phenyl)-1-propyl-1H-pyrrole-3-carboxylate

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Technology Process of ethyl 5-(4-chlorophenyl)-2-methyl-4-(3-(4-(4-nitrophenyl)piperazin-1-yl)phenyl)-1-propyl-1H-pyrrole-3-carboxylate

There total 1 articles about ethyl 5-(4-chlorophenyl)-2-methyl-4-(3-(4-(4-nitrophenyl)piperazin-1-yl)phenyl)-1-propyl-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1384513-05-6
ethyl 2-acetyl-4-(4-chlorophenyl)-3-(3-iodophenyl)-4-oxobutanoate

: 1402141-68-7
ethyl 5-(4-chlorophenyl)-2-methyl-4-(3-(4-(4-nitrophenyl)piperazin-1-yl)phenyl)-1-propyl-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 6 h / 20 °C

2: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 8 h / 80 °C / Inert atmosphere

With copper(l) iodide; potassium carbonate; L-proline; In methanol; dimethyl sulfoxide; 2: |Ullmann Condensation;
DOI:10.1021/jm3010306

Reference yield: 95.0%

: 1402141-68-7
ethyl 5-(4-chlorophenyl)-2-methyl-4-(3-(4-(4-nitrophenyl)piperazin-1-yl)phenyl)-1-propyl-1H-pyrrole-3-carboxylate

: 1402141-70-1
5-(4-chlorophenyl)-2-methyl-4-(3-(4-(4-nitrophenyl)piperazin-1-yl)phenyl)-1-propyl-1H-pyrrole-3-carboxylic acid

Guidance literature:: ethyl 5-(4-chlorophenyl)-2-methyl-4-(3-(4-(4-nitrophenyl)piperazin-1-yl)phenyl)-1-propyl-1H-pyrrole-3-carboxylate; With sodium hydroxide; In 1,4-dioxane; ethanol; water; for 20h; Reflux; Inert atmosphere;

With hydrogenchloride; In 1,4-dioxane; ethanol; water; Inert atmosphere;
DOI:10.1021/jm3010306

Reference yield:

: 1402141-68-7
ethyl 5-(4-chlorophenyl)-2-methyl-4-(3-(4-(4-nitrophenyl)piperazin-1-yl)phenyl)-1-propyl-1H-pyrrole-3-carboxylate

: C₃₁H₃₃ClN₄O₂

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / 1,4-dioxane; ethanol; water / 20 h / Reflux; Inert atmosphere

1.2: Inert atmosphere

2.1: palladium on activated charcoal; hydrogen / methanol / 20 °C / Inert atmosphere

With palladium on activated charcoal; hydrogen; sodium hydroxide; In 1,4-dioxane; methanol; ethanol; water;
DOI:10.1021/jm3010306