4-chloro-2-methylbenzaldehyde ethylene acetal

Base Information

Chemical Name:4-chloro-2-methylbenzaldehyde ethylene acetal
CAS No.:371785-35-2
Molecular Formula:C₁₀H₁₁ClO₂
Molecular Weight:198.649
Hs Code.:

Synonyms:4-chloro-2-methylbenzaldehyde ethylene acetal

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Chemical Property of 4-chloro-2-methylbenzaldehyde ethylene acetal

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Technology Process of 4-chloro-2-methylbenzaldehyde ethylene acetal

There total 1 articles about 4-chloro-2-methylbenzaldehyde ethylene acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 40137-29-9
2-methyl-4-chlorobenzaldehyde

: 107-21-1
ethylene glycol

: 371785-35-2
4-chloro-2-methylbenzaldehyde ethylene acetal

Guidance literature:: With toluene-4-sulfonic acid; In benzene; at 150 ℃; for 12h;
DOI:10.3987/COM-01-9271

Reference yield: 78.0%

: 1450-14-2
1,1,1,2,2,2-hexamethyldisilane

: 371785-35-2
4-chloro-2-methylbenzaldehyde ethylene acetal

: 371785-37-4
2-methyl-4-trimethylsilylbenzaldehyde ethylene acetal

Guidance literature:: With sodium methylate; In N,N,N,N,N,N-hexamethylphosphoric triamide; at 20 ℃; for 6h;
DOI:10.3987/COM-01-9271

Reference yield:

: 371785-35-2
4-chloro-2-methylbenzaldehyde ethylene acetal

: trans-2-(2-methylphenyl)-6-phenyl-4-piperidone

Guidance literature:: Multi-step reaction with 5 steps

1.1: 78 percent / NaOMe / hexamethylphosphoric acid triamide / 6 h / 20 °C

2.1: 47 percent / HCl / tetrahydrofuran; H₂O / 0.05 h / 0 °C

3.1: molecular sieves 4A / diethyl ether / 12 h / 20 °C

4.1: TMSOTf / CH₂Cl₂ / 12 h / 20 °C

5.1: TMSOTf / CH₂Cl₂ / 12 h / 20 °C

5.2: 71 percent / TBAF / tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; sodium methylate; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; water;
DOI:10.3987/COM-01-9271