(3R)-3-((((1,1-dimethylethyl)-diphenyl)-silyloxy)methyl)-4-phenylsulfonyl-2,3-dihydrofuran

Base Information

Chemical Name:(3R)-3-((((1,1-dimethylethyl)-diphenyl)-silyloxy)methyl)-4-phenylsulfonyl-2,3-dihydrofuran
CAS No.:287933-71-5
Molecular Formula:C₂₇H₃₀O₄SSi
Molecular Weight:478.684
Hs Code.:

Synonyms:(3R)-3-((((1,1-dimethylethyl)-diphenyl)-silyloxy)methyl)-4-phenylsulfonyl-2,3-dihydrofuran

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Chemical Property of (3R)-3-((((1,1-dimethylethyl)-diphenyl)-silyloxy)methyl)-4-phenylsulfonyl-2,3-dihydrofuran

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Technology Process of (3R)-3-((((1,1-dimethylethyl)-diphenyl)-silyloxy)methyl)-4-phenylsulfonyl-2,3-dihydrofuran

There total 4 articles about (3R)-3-((((1,1-dimethylethyl)-diphenyl)-silyloxy)methyl)-4-phenylsulfonyl-2,3-dihydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 287933-70-4
(3S)-4-phenylsulfonyl-2,3-dihydrofuran-3-methanol

: 287933-71-5
(3R)-3-((((1,1-dimethylethyl)-diphenyl)-silyloxy)methyl)-4-phenylsulfonyl-2,3-dihydrofuran

Guidance literature:: With dmap; triethylamine;
DOI:10.1016/S0040-4039(00)00467-6

Reference yield:

: 38238-75-4
(E)-2-chloroethenyl phenyl sulfone

: 287933-71-5
(3R)-3-((((1,1-dimethylethyl)-diphenyl)-silyloxy)methyl)-4-phenylsulfonyl-2,3-dihydrofuran

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran / 0.5 h / -23 °C

1.2: 78 percent / tetrahydrofuran / 1 h / -23 - 0 °C

2.1: 60 percent / LHMDS / tetrahydrofuran / 0.5 h / -78 - 0 °C

3.1: 96 percent / Et₃N; DMAP / CH₂Cl₂ / 20 h / 20 °C

With dmap; sodium hydride; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1007/s007060200024

Reference yield:

: 287933-69-1
(S)-2-((E)-2-Benzenesulfonyl-vinyloxymethyl)-oxirane

: 287933-71-5
(3R)-3-((((1,1-dimethylethyl)-diphenyl)-silyloxy)methyl)-4-phenylsulfonyl-2,3-dihydrofuran

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / LHDMS / tetrahydrofuran

2: 100 percent / Et₃N; DMAP

With dmap; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; 1: Cyclization / 2: Silylation;
DOI:10.1016/S0040-4039(00)00467-6