7b-phenyl-7bH-oxazirino<2,3-b><1,2>benzisothiazole 3,3-dioxide

Base Information

• Chemical Name: 7b-phenyl-7bH-oxazirino<2,3-b><1,2>benzisothiazole 3,3-dioxide
• CAS No.: 124401-11-2
• Molecular Formula: C₁₃H₉NO₃S
• Molecular Weight: 259.285
• Mol file: 124401-11-2.mol

Synonyms:7b-phenyl-7bH-oxazirino<2,3-b><1,2>benzisothiazole 3,3-dioxide

Chemical Property of 7b-phenyl-7bH-oxazirino<2,3-b><1,2>benzisothiazole 3,3-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7b-phenyl-7bH-oxazirino<2,3-b><1,2>benzisothiazole 3,3-dioxide

There total 8 articles about 7b-phenyl-7bH-oxazirino<2,3-b><1,2>benzisothiazole 3,3-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-phenylbenzo[d]isothiazole-1,1-dioxide (53440-57-6) → 7b-phenyl-7bH-oxazirino<2,3-b><1,2>benzisothiazole 3,3-dioxide (124401-11-2)

Guidance literature:

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In chloroform; water; at 0 ℃;

DOI:10.1246/bcsj.60.1457

Reference yield:

saccharin (81-07-2) → 7b-phenyl-7bH-oxazirino<2,3-b><1,2>benzisothiazole 3,3-dioxide (124401-11-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / tetrahydrofuran / 4 h / -78 °C

2: 74 percent / K₂CO₃, m-chloroperbenzoic acid / CH₂Cl₂; H₂O

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/jo00291a028

Reference yield:

phenylmagnesium bromide (100-58-3) → 7b-phenyl-7bH-oxazirino<2,3-b><1,2>benzisothiazole 3,3-dioxide (124401-11-2)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 25 °C / Inert atmosphere; Schlenk technique

2: toluene-4-sulfonic acid / toluene / Inert atmosphere; Schlenk technique; Reflux

3: potassium carbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / Inert atmosphere; Schlenk technique

With potassium carbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1021/ol503118v

upstream raw materials:

3-phenylbenzo[d]isothiazole-1,1-dioxide

3-ethoxy-benzo[d]isothiazole 1,1-dioxide

phenyllithium

saccharin

Downstream raw materials:

(S)-3-phenyl-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide

(R)-3-phenyl-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide

3-phenylbenzo[d]isothiazole-1,1-dioxide

methylphenylsulfonate