(±)-2,3-bis(4-chlorophenyl)propanoic acid

Base Information

• Chemical Name: (±)-2,3-bis(4-chlorophenyl)propanoic acid
• CAS No.: 1743-54-0
• Molecular Formula: C₁₅H₁₂Cl₂O₂
• Molecular Weight: 295.165

Synonyms:(±)-2,3-bis(4-chlorophenyl)propanoic acid

Chemical Property of (±)-2,3-bis(4-chlorophenyl)propanoic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2,3-BIS-(4-CHLOROPHENYL)PROPANOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (±)-2,3-bis(4-chlorophenyl)propanoic acid

There total 6 articles about (±)-2,3-bis(4-chlorophenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

carbon dioxide (124-38-9,18923-20-1) + 4,4'-dichlorostylbene (5121-74-4) → (±)-2,3-bis(4-chlorophenyl)propanoic acid (1743-54-0)

Guidance literature:

4,4'-dichlorostylbene; With 9-borabicyclo[3.3.1]nonane dimer; In 1,2-dimethoxyethane; at 70 ℃; for 24h; Glovebox;

carbon dioxide; With cesium fluoride; In 1,2-dimethoxyethane; at 120 ℃; for 24h; regioselective reaction; Glovebox;

DOI:10.1039/c9sc02467k

Reference yield:

(E)-2,3-bis(4-chlorophenyl)-2-propenoic acid (1657-63-2) → (±)-2-(4-chlorophenyl)-3-phenylpropanoic acid (787-27-9) + (±)-2,3-bis(4-chlorophenyl)propanoic acid (1743-54-0)

Guidance literature:

With palladium/alumina; hydrogen; In water; N,N-dimethyl-formamide; at 21.84 ℃; for 4h; under 750.075 Torr;

DOI:10.1016/j.molcata.2010.09.013

Reference yield:

(E)-2,3-bis(4-chlorophenyl)-2-propenoic acid (1657-63-2) → (±)-2-(4-chlorophenyl)-3-phenylpropanoic acid (787-27-9) + (2E)-2-(4-chlorophenyl)-3-phenylprop-2-enoic acid (10465-70-0,73720-02-2,20432-20-6) + (±)-2,3-bis(4-chlorophenyl)propanoic acid (1743-54-0)

Guidance literature:

With palladium/alumina; hydrogen; cinchonidine; In water; N,N-dimethyl-formamide; at 21.84 ℃; for 6h; under 750.075 Torr; enantioselective reaction;

DOI:10.1016/j.molcata.2010.09.013

upstream raw materials:

2,3-bis(4-chlorophenyl)propanenitrile

(E)-2,3-bis(4-chlorophenyl)-2-propenoic acid

carbon dioxide

4,4'-dichlorostylbene

Downstream raw materials:

2-(p-Chlor-phenyl)-6-chlor-indanon-⁽¹⁾

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