787-27-9

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-chlorophenyl)-3-phenylpropanoic acid is used as an analgesic and anti-inflammatory agent for managing pain and inflammation in conditions such as arthritis and other joint disorders. Its mechanism of action involves reducing prostaglandin levels, which are chemicals that contribute to inflammation and pain.
Used in Medical Treatments:
2-(4-chlorophenyl)-3-phenylpropanoic acid is used as a short-term pain management solution to provide relief from the discomfort caused by various joint conditions. It is available in both oral and injectable forms, allowing for flexible treatment options.
However, it is important to note that 2-(4-chlorophenyl)-3-phenylpropanoic acid, like other NSAIDs, carries potential risks such as gastrointestinal bleeding, ulcers, and kidney problems. Therefore, it should be used with caution and under medical supervision.

Upstream product

• 1878-66-6 4-chlorophenylacetic Acid 
• 100-44-7 benzyl chloride 
• 10465-70-0 (2E)-2-(4-chlorophenyl)-3-phenylprop-2-enoic acid 
• 1657-63-2 (E)-2,3-bis(4-chlorophenyl)-2-propenoic acid 
• 1657-49-4 1-chloro-4-styrylbenzene 
• 124-38-9 carbon dioxide 

Downstream Products

• 14087-87-7 2-(4-chlorophenyl)-2,3-dihydro-1H-inden-1-one 

Relevant academic research and scientific papers

Copper-catalyzed carboxylation of hydroborated disubstituted alkenes and terminal alkynes with cesium fluoride

A protocol for the hydrocarboxylation of disubstituted alkenes and terminal alkynes providing access to different secondary carboxylic acids and malonic acid derivatives has been developed. This methodology relies on an initial hydroboration using 9-BBN followed by carboxylation with carbon dioxide in the presence of a copper catalyst and the additive, cesium fluoride. Different cyclohexene, styrene, and stilbene derivatives could be utilized, and alkynes could be transformed into their corresponding dicarboxylic acids in good yields. Finally, six different terpenoids were carboxylated using the developed procedure. (Chemical Equation Presented).

GUANIDINE DERIVATIVES AS TRPC MODULATORS

The present invention is directed to guanidine derivatives as inhibitors of transient receptor potential canonical channels (TRPC channels), in particular TRPC3 and/or TRPC6 and/or TRPC7 activity, more particularly TRPC6 activity. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders mediated by TRPC channels (Formula (I))

Reactions of chlorine substituted (E)-2,3-diphenylpropenoic acids over cinchonidine-modified Pd: Enantioselective hydrogenation versus hydrodechlorination

The effect of the chlorine position on the C-Cl bond hydrogenolysis and the enantioselective hydrogenation of Cl substituted (E)-2,3-diphenylpropenoic acid derivatives has been studied over cinchonidine-modified Pd/Al2O 3. In contrast to the fast hydrodechlorination of the β-phenyl-para-Cl substituted acids the Cl on the α-phenyl ring was barely hydrogenolized. These observations were interpreted by the different arrangements of the two phenyl rings on the surface, with the α- and β-phenyl rings adsorbed tilted and parallel, respectively. The results confirmed the beneficial effect of the α-phenyl-ortho-substituents on the chiral discrimination, thus the 2,3-diphenylpropionic acids substituted by Cl on the α-phenyl ring could be prepared in good yields and optical purities. The conclusions were used for the rational design of an acid, i.e. (E)-2-(2-methoxyphenyl)-3-(3,4-difluorophenyl)propenoic acid, which afforded the best optical purity (ee up to 95% at 295 K) described until now in this heterogeneous system.