5121-74-4

Basic information

• Product Name: 1-chloro-4-((E)-2-(4-chlorophenyl)ethenyl)benzene
• Synonyms: 1,1'-ethene-1,2-diylbis(4-chlorobenzene)
• CAS NO: 5121-74-4
• Molecular Formula: C₁₄H₁₀Cl₂
• Molecular Weight: 249.1352
• Mol File: 5121-74-4.mol
• Article Data: 119

Chemical Properties

• Boiling Point: 360°C at 760 mmHg
• Flash Point: 167.2°C
• Density: 1.267g/cm³
• Vapor Pressure: 4.76E-05mmHg at 25°C
• Refractive Index: 1.67
• CAS DataBase Reference: 1-chloro-4-((E)-2-(4-chlorophenyl)ethenyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-4-((E)-2-(4-chlorophenyl)ethenyl)benzene(5121-74-4)
• EPA Substance Registry System: 1-chloro-4-((E)-2-(4-chlorophenyl)ethenyl)benzene(5121-74-4)

Safety Data

• Hazardous Substances Data: 5121-74-4(Hazardous Substances Data)

Usage

General Description

1-chloro-4-((E)-2-(4-chlorophenyl)ethenyl)benzene, also known as Clomiphene, is a synthetic estrogen that is commonly used as a fertility drug. It belongs to the class of organic compounds called phenyl alkenes which contain a benzene ring and an aliphatic chain. Clomiphene works by blocking estrogen receptors in the hypothalamus, which in turn stimulates the release of follicle-stimulating hormone and luteinizing hormone, leading to ovulation in women. 1-chloro-4-((E)-2-(4-chlorophenyl)ethenyl)benzene is also used in the treatment of male infertility and is sometimes prescribed off-label to treat other conditions like polycystic ovary syndrome. However, it may cause some side effects such as hot flushes, abdominal discomfort, and nausea, and should be used under the supervision of a healthcare professional.

Upstream product

• 908094-04-2 phenyldiazomethane 
• 118-75-2 chloranil 
• 10311-79-2 1-chloro-1,2-bis(p-chlorophenyl)ethane 
• 78-08-0 Triethoxyvinylsilane 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 
• 7647-01-0 hydrogenchloride 
• 50-29-3 p,p'-DDT 
• 1073-67-2 4-vinylbenzyl chloride 
• 637-87-6 1-Chloro-4-iodobenzene 
• 59305-51-0 1-chloro-4-<(phenylseleno)methyl>benzene 
• 104-88-1 4-chlorobenzaldehyde 
• 5586-88-9 1-(4-chlorophenyl)propan-2-one 
• 1334478-56-6 Br^(1-)*C₂₀H₁₆Cl₂N₃⁽¹⁺⁾ 
• 72-54-8 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethane 

Downstream Products

• 38424-26-9 meso-p,p'-dichlorostilbene dibromide 
• 67111-67-5 (R,R)-(+)-1,2-bis(4-chlorophenyl)ethane-1,2-diol 
• 103-29-7 1,1'-(1,2-ethanediyl)bisbenzene 
• 325811-01-6 (S,S)-(-)-1,2-di(p-chlorophenyl)ethane-1,2-diol 
• 1454309-56-8 2-bromo-5-chloro-3-(4-chlorophenyl)-1H-indene 
• 1454309-38-6 2-bromo-6-chloro-1-(4-chlorophenyl)-1H-indene 
• 1609133-12-1 C₂₃H₁₂Cl₂O₃ 
• 5216-35-3 1,2-bis(4-chlorophenyl)ethane 
• 130272-00-3 8-Methoxy-3,4,5,7-tetrahydro-1,3,7-trimethyl-anti-10,syn-11-bis(4-chlorphenyl)-4,5-ethano-1H-purin-2,6-dion 
• 130168-08-0 8-Methoxy-3,4,5,7-tetrahydro-1,3,7-trimethyl-syn-10,anti-11-bis(4-chlorphenyl)-4,5-ethano-1H-purin-2,6-dion 
• 79183-98-5 1,2-dibromo-1,2-di-(p-chlorophenyl)-ethane 
• 16740-47-9 meso-4.4'.α.α'-tetrachloro-bibenzyl 
• 16740-47-9 racem.-4.4'.α.α'-tetrachloro-bibenzyl 
• 62006-50-2 trans-1,2-bis-(p-chlorophenyl)ethane oxide 

Relevant articles and documents

Efficient preparation method of symmetric diarylethene compound

The invention belongs to the technical field of fine chemicals and related chemistry, and provides an efficient preparation method of a symmetric diarylethene compound. The method comprises the following steps: with halomethyl-containing aromatic hydrocarbon and derivatives thereof as raw materials, conducting reacting at 100 DEG C for 12 hours in the presence of a catalyst, alkali, additives andan anhydrous organic solvent so as to obtain the corresponding diarylethene compound with symmetry. The method has the beneficial effects that no transition metal reaction exists, reaction conditionsare mild, operation is simple and convenient, the possibility of industrialization is realized, and the diarylethene compound is obtained at high yield; and the diarylethene compound synthesized by using the method can be further functionalized to obtain various compounds, and is applied to development and research of natural products, functional materials and fine chemicals.

Site-Selective C–H Benzylation of Alkanes with N-Triftosylhydrazones Leading to Alkyl Aromatics

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Selenenate Anions (PhSeO?) as Organocatalyst: Synthesis of trans-Stilbenes and a PPV Derivative

The selenenate anion (RSeO?) is introduced as an active organocatalyst for the dehydrohalogen coupling of benzyl halides to form trans-stilbenes. It is shown that RSeO? is a more reactive catalyst than the previously reported sulfur analogues (sulfenate anion, RSO?) and selenolate anions (RSe?) in the aforementioned reaction. This catalytic system was also applied to the benzylic-chloromethyl-coupling polymerization (BCCP) of a bis-chloromethyl arene to form ppv (poly(p-phenylene vinylene))-type polymers with high yields, Mn (average molecular weight) up to 13,000 and ? (dispersity) of 1.15. (Figure presented.).