90433-74-2

Basic information

• Product Name: 4-benzoyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester
• Synonyms: 4-benzoyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester
• CAS NO: 90433-74-2
• Molecular Weight: 271.316
• Mol File: 90433-74-2.mol

Chemical Properties

• CAS DataBase Reference: 4-benzoyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzoyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester(90433-74-2)
• EPA Substance Registry System: 4-benzoyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester(90433-74-2)

Safety Data

• Hazardous Substances Data: 90433-74-2(Hazardous Substances Data)

Upstream product

• 2199-44-2 3,5-dimethyl-2-ethoxycarbonyl-1H-pyrrole 
• 98-88-4 benzoyl chloride 
• 65-85-0 benzoic acid 
• 141-97-9 ethyl acetoacetate 
• 93-91-4 1-phenylbutan-1,3-dione 
• 62264-99-7 methyl 5-acetyl-2,4-dimethyl-1H-pyrrole-3-carboxylate 

Downstream Products

• 131475-13-3 ethyl 4-benzyl-3,5-dimethyl-1H-pyrrole-2-carboxylate 
• 1361938-25-1 C₁₇H₁₉NO₃ 
• 1361938-26-2 C₁₅H₁₅NO₃ 
• 71858-27-0 4-benzoyl-5-formyl-3-methyl-pyrrole-2-carboxylic acid ethyl ester 
• 24836-10-0 (2,4-dimethyl-1H-pyrrol-3-yl)(phenyl)methanone 
• 2199-44-2 3,5-dimethyl-2-ethoxycarbonyl-1H-pyrrole 
• 94-33-7 C₉H₁₀O₃ 
• 20587-61-5 diethylene glycol benzoate 
• 120-56-9 triethylene glycol dibenzoate 
• 356068-84-3 4-benzoyl-3,5-dimethyl-pyrrole-2-carboxylic acid 

Relevant articles and documents

PYRROLE COMPOUND

Provided is a highly safe and effective compound represented by the following general formula (1) or a salt thereof which acts on tubulin and has an anticancer effect, wherein Ar represents an aryl group or a heteroaryl group; Z1, Z2

CYCLIC AMIDE DERIVATIVE

Provided is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. (In the formula, A is C6-10 arylene, etc.; R1a, R1b and R1c each independently is a hydrogen atom, a halogen atom, a C1-4 alkyl group, a C1-4 alkoxy group, etc.; R2 is an optionally substituted C6-10 aryl group, an optionally substituted 5- to 12-membered monocyclic or polycyclic heteroaryl group, an optionally substituted C7-16 aralkyl group, etc.; m is 0, etc.; n is an integer of 0 to 2.)

P53 TUMOR SUPPRESSOR PROTEIN ACTIVATING

The invention provides a compound of formula (I), wherein X, L1-4 and R1-4 are as defined herein, with the proviso that the compound is not (i) 4-benzoyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester; (ii) 4-(2,5-difluorobenz

Phosphoric acid-promoted synthesis of 4-acylpyrrole-2-carboxylic esters and dipyrryl ketones from mixed anhydrides

An efficient synthesis of 4-acylpyrrole-2-carboxylic esters utilizing a phosphoric acid-catalyzed mixed anhydride system is described. The new route also enables the preparation of dipyrryl ketones and N-confused dipyrryl ketones.

Regioselective pyrrole synthesis from asymmetric β-diketone and conversion to sterically hindered porphyrin

The condensation of asymmetric β-diketones with α-oximinoacetoacetate esters affords pyrroles regioselectively. The mechanism of the regioselectivity is studied using 13C-NMR spectroscopy. Pyrrole having a neopentyl group at the 4-position is synthesized by the method, and further converted to a steric hindered porphyrin in good yield.

Deacylation of Pyrrole and other Aromatic Ketones

Ethyl 4-acetyl-3,5-dimethyl-1H-pyrrole-2-carboxylate (1a) reacts rapidly with ethylene glycol in refluxing benzene with p-toluenesulfonic acid or perchloric acid as a catalyst to give ethyl 3,5-dimethyl-1H-pyrrole-2-carboxylate (3) in high yield (96 percent).Various 2- and 3-acylpyrroles can be efficiently deacylated by using this procedure.Other ketones which undergo deacylation include phenyl(2-phenylindol-3-yl)methanone (19), 1-(5-methyl-1-phenylpyrazol-4-yl)ethanone (20), and 2,4-dimethoxybenzophenone.Certain pyrrole ketones where the acyl group is flanked by two ring methyl groups are also cleaved under acidic conditions by using ethanedithiol.