Technology Process of methyl 2-hydroxy-6-iodo-3,4-dimethoxybenzoate
There total 7 articles about methyl 2-hydroxy-6-iodo-3,4-dimethoxybenzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron tribromide;
In
dichloromethane; water;
at -78 ℃;
for 0.5h;
Inert atmosphere;
DOI:10.1021/ja411146x
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium nitrite; hydrogenchloride; phenylphosphane / water / 0.25 h / 0 - 5 °C / Inert atmosphere
1.2: 0 - 5 °C / Inert atmosphere
2.1: dihydrogen peroxide; potassium hydroxide / methanol / 1.17 h / 65 °C
3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / Inert atmosphere
4.1: dichloromethane / 0.5 h / Inert atmosphere
5.1: boron tribromide / water; dichloromethane / 0.5 h / -78 °C / Inert atmosphere
With
hydrogenchloride; oxalyl dichloride; dihydrogen peroxide; boron tribromide; N,N-dimethyl-formamide; phenylphosphane; potassium hydroxide; sodium nitrite;
In
methanol; dichloromethane; water;
DOI:10.1021/ja411146x
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: nitric acid; acetic acid / 1.5 h / 0 °C / Inert atmosphere
2.1: iron; ferrous(II) sulfate heptahydrate / water; ethanol / 4 h / Inert atmosphere; Reflux
3.1: sodium nitrite; hydrogenchloride; phenylphosphane / water / 0.25 h / 0 - 5 °C / Inert atmosphere
3.2: 0 - 5 °C / Inert atmosphere
4.1: dihydrogen peroxide; potassium hydroxide / methanol / 1.17 h / 65 °C
5.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / Inert atmosphere
6.1: dichloromethane / 0.5 h / Inert atmosphere
7.1: boron tribromide / water; dichloromethane / 0.5 h / -78 °C / Inert atmosphere
With
hydrogenchloride; ferrous(II) sulfate heptahydrate; oxalyl dichloride; dihydrogen peroxide; nitric acid; boron tribromide; iron; acetic acid; N,N-dimethyl-formamide; phenylphosphane; potassium hydroxide; sodium nitrite;
In
methanol; ethanol; dichloromethane; water;
DOI:10.1021/ja411146x
