3'-O-acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydrothymidine

Base Information

• Chemical Name: 3'-O-acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydrothymidine
• CAS No.: 1370548-51-8
• Molecular Formula: C₃₈H₄₂N₂O₁₀
• Molecular Weight: 686.759
• Mol file: 1370548-51-8.mol

Synonyms:3'-O-acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydrothymidine

Chemical Property of 3'-O-acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydrothymidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-O-acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydrothymidine

There total 1 articles about 3'-O-acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydrothymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

di-tert-butyl dicarbonate (24424-99-5) + 3'-O-acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-3,4-dihydrothymidine (40615-37-0) → 3'-O-acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydrothymidine (1370548-51-8)

Guidance literature:

With pyridine; dmap; triethylamine; at 20 ℃; for 1h;

DOI:10.1002/cbdv.201100103

Reference yield: 100.0%

3'-O-acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydrothymidine (1370548-51-8) → 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydrothymidine (1370548-54-1)

Guidance literature:

With ammonium hydroxide; In methanol; at 20 ℃; for 2.5h;

DOI:10.1002/cbdv.201100103

Reference yield:

3'-O-acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydrothymidine (1370548-51-8) → sodium 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-3'-O-(carboxylatomethyl)-2'-deoxy-3,4-dihydrothymidine (1370548-57-4)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium hydroxide / methanol / 2.5 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 24 h / 20 °C

3: sodium hydroxide / tetrahydrofuran / 0.5 h / 20 °C

With ammonium hydroxide; sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1002/cbdv.201100103

upstream raw materials:

di-tert-butyl dicarbonate

3'-O-acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-3,4-dihydrothymidine

Downstream raw materials:

sodium 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-3'-O-(carboxylatomethyl)-2'-deoxy-3,4-dihydrothymidine

5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydrothymidine

3'-O-benzyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3-[(tert-butoxy)carbonyl]-2'-deoxy-3,4-dihydrothymidine