2-{3-[3-methoxy-2-(methoxymethoxy)phenyl]prop-2-ynoyl}phenyl methyl carbonate

Base Information

Chemical Name:2-{3-[3-methoxy-2-(methoxymethoxy)phenyl]prop-2-ynoyl}phenyl methyl carbonate
CAS No.:1607814-75-4
Molecular Formula:C₂₀H₁₈O₇
Molecular Weight:370.359
Hs Code.:

Synonyms:2-{3-[3-methoxy-2-(methoxymethoxy)phenyl]prop-2-ynoyl}phenyl methyl carbonate

Suppliers and Price of 2-{3-[3-methoxy-2-(methoxymethoxy)phenyl]prop-2-ynoyl}phenyl methyl carbonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2-{3-[3-methoxy-2-(methoxymethoxy)phenyl]prop-2-ynoyl}phenyl methyl carbonate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of 2-{3-[3-methoxy-2-(methoxymethoxy)phenyl]prop-2-ynoyl}phenyl methyl carbonate

There total 3 articles about 2-{3-[3-methoxy-2-(methoxymethoxy)phenyl]prop-2-ynoyl}phenyl methyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 201230-82-2
carbon monoxide

: 1607814-72-1
2-iodophenyl methyl carbonate

: 634153-25-6
1-ethynyl-3-metyhoxy-2-(2-methoxymethoxy)benzene

: 1607814-75-4
2-{3-[3-methoxy-2-(methoxymethoxy)phenyl]prop-2-ynoyl}phenyl methyl carbonate

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 12h; under 38002.6 Torr; Autoclave;
DOI:10.1016/j.tet.2014.03.073

Reference yield:

: 148-53-8
3-methoxy-2-hydroxybenzaldehyde

: 1607814-75-4
2-{3-[3-methoxy-2-(methoxymethoxy)phenyl]prop-2-ynoyl}phenyl methyl carbonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

1.3: -78 - 0 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 12 h / 80 °C / 38002.6 Torr / Autoclave

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; 3.1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.tet.2014.03.073

Reference yield:

: 533-58-4
2-Iodophenol

: 1607814-75-4
2-{3-[3-methoxy-2-(methoxymethoxy)phenyl]prop-2-ynoyl}phenyl methyl carbonate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 12 h / 80 °C / 38002.6 Torr / Autoclave

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 2: |Sonogashira Cross-Coupling;
DOI:10.1016/j.tet.2014.03.073