(7,8-trans)-7-benzyl 8-methyl 1,4-dioxaspiro[4.4]nonane-7,8-dicarboxylate

Base Information

Chemical Name:(7,8-trans)-7-benzyl 8-methyl 1,4-dioxaspiro[4.4]nonane-7,8-dicarboxylate
CAS No.:1445591-67-2
Molecular Formula:C₁₇H₂₀O₆
Molecular Weight:320.342
Hs Code.:

Synonyms:(7,8-trans)-7-benzyl 8-methyl 1,4-dioxaspiro[4.4]nonane-7,8-dicarboxylate

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Chemical Property of (7,8-trans)-7-benzyl 8-methyl 1,4-dioxaspiro[4.4]nonane-7,8-dicarboxylate

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Technology Process of (7,8-trans)-7-benzyl 8-methyl 1,4-dioxaspiro[4.4]nonane-7,8-dicarboxylate

There total 2 articles about (7,8-trans)-7-benzyl 8-methyl 1,4-dioxaspiro[4.4]nonane-7,8-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445591-65-0,164916-54-5
(1,2-trans)-1-benzyl 2-methyl 4-oxocyclopentane-1,2-dicarboxylate

: 107-21-1
ethylene glycol

: 1445591-67-2
(7,8-trans)-7-benzyl 8-methyl 1,4-dioxaspiro[4.4]nonane-7,8-dicarboxylate

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 2h; Dean-Stark; Reflux;

Reference yield:

: 115694-82-1
(1S,2S)-2-(methoxycarbonyl)-4-oxocyclopentanecarboxylic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 1445591-67-2
(7,8-trans)-7-benzyl 8-methyl 1,4-dioxaspiro[4.4]nonane-7,8-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / toluene / 0.67 h / 70 °C / Inert atmosphere

1.2: 4 h / 70 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / toluene / 2 h / Dean-Stark; Reflux

With toluene-4-sulfonic acid; 1,1'-carbonyldiimidazole; In toluene;

Reference yield:

: 1445591-67-2
(7,8-trans)-7-benzyl 8-methyl 1,4-dioxaspiro[4.4]nonane-7,8-dicarboxylate

: 1445590-61-3
(S)-methyl 2-((7,8-trans)-8-(5-(4-bromophenyl)-1H-imidazol-2-yl)-1,4-dioxaspiro[4.4]nonane-7-carboxamido)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen; palladium 10% on activated carbon / methanol

2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.08 h / 0 - 5 °C

3: ammonium acetate / N,N-dimethyl-formamide / 2 h / 140 °C

4: sodium hydroxide; water / methanol / 3 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h / 20 °C

With palladium 10% on activated carbon; ammonium acetate; water; hydrogen; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In methanol; N,N-dimethyl-formamide;