2-{4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-5,7-difluoro-3H-quinazolin-4-one

Base Information

• Chemical Name: 2-{4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-5,7-difluoro-3H-quinazolin-4-one
• CAS No.: 1253732-44-3
• Molecular Formula: C₂₄H₃₀F₂N₂O₃Si
• Molecular Weight: 460.596
• Mol file: 1253732-44-3.mol

Synonyms:2-{4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-5,7-difluoro-3H-quinazolin-4-one

Chemical Property of 2-{4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-5,7-difluoro-3H-quinazolin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-5,7-difluoro-3H-quinazolin-4-one

There total 5 articles about 2-{4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-5,7-difluoro-3H-quinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

2-amino-4,6-difluoro-benzamide (893428-66-5) + 4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylbenzaldehyde (1044872-73-2) → 2-{4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-5,7-difluoro-3H-quinazolin-4-one (1253732-44-3)

Guidance literature:

With toluene-4-sulfonic acid; sodium hydrogensulfite; In N,N-dimethyl acetamide; at 120 ℃; for 16h;

Reference yield:

2-(tert-butyldimethylsilyloxy)ethyl bromide (86864-60-0) → 2-{4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-5,7-difluoro-3H-quinazolin-4-one (1253732-44-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride; potassium iodide / N,N-dimethyl-formamide / 14 h / 70 °C

2: sodium hydrogen sulfate; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 14 h / 155 °C

With sodium hydrogen sulfate; sodium hydride; toluene-4-sulfonic acid; potassium iodide; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

syringic aldehyde (134-96-3) → 2-{4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-5,7-difluoro-3H-quinazolin-4-one (1253732-44-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride; potassium iodide / N,N-dimethyl-formamide / 14 h / 70 °C

2: sodium hydrogen sulfate; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 14 h / 155 °C

With sodium hydrogen sulfate; sodium hydride; toluene-4-sulfonic acid; potassium iodide; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;

upstream raw materials:

2-amino-4,6-difluoro-benzamide

4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylbenzaldehyde

syringic aldehyde

2-(tert-butyldimethylsilyloxy)ethyl bromide

Downstream raw materials:

2-{4-[2-(tert-butyldiphenylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-7-fluoro-5-methoxy-3H-quinazolin-4-one

7-(2-benzyloxy-ethoxy)-2-[4-(2-hydroxy-ethoxy)-3,5-dimethyl-phenyl]-5-methoxy-3H-quinazolin-4-one

7-fluoro-2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5-methoxy-3H-quinazolin-4-one

5,7-difluoro-2-[4-(2-hydroxy-ethoxy)-3,5-dimethyl-phenyl]-3H-quinazolin-4-one