N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucine benzyl ester

Base Information

• Chemical Name: N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucine benzyl ester
• CAS No.: 102307-07-3
• Molecular Formula: C₂₈H₃₈N₄O₆
• Molecular Weight: 526.633
• Mol file: 102307-07-3.mol

Synonyms:N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucine benzyl ester

Chemical Property of N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucine benzyl ester

There total 2 articles about N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

L-phenylalanyl-L-leucine benzyl ester (63649-15-0) + C12H13Cl3N2O4 (102307-06-2) → N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucine benzyl ester (102307-07-3)

Guidance literature:

With benzotriazol-1-ol; In N,N-dimethyl-formamide; at 23 ℃; for 15h;

DOI:10.1021/jm00157a018

Reference yield:

t-butoxycarbonylhydrazine (870-46-2) → N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucine benzyl ester (102307-07-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / CHCl₃ / 23 °C

2: 81 percent / N-hydroxybenzotriazole (HOBt) / dimethylformamide / 15 h / 23 °C

With benzotriazol-1-ol; triethylamine; In chloroform; N,N-dimethyl-formamide;

DOI:10.1021/jm00157a018

Reference yield: 92.0%

N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucine benzyl ester (102307-07-3) → N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucine (102307-08-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; for 4h; under 760 Torr;

DOI:10.1021/jm00157a018

upstream raw materials:

L-phenylalanyl-L-leucine benzyl ester

C₁₂H₁₃Cl₃N₂O₄

t-butoxycarbonylhydrazine

Downstream raw materials:

N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucine

C₃₅H₆₁N₁₃O₇

N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucyl-N^G-nitroarginyl-N^G-nitroarginylisoleucine methyl ester