2-amino-3-(4'-fluorobenzoyl)benzo[b]furan

Base Information

• Chemical Name: 2-amino-3-(4'-fluorobenzoyl)benzo[b]furan
• CAS No.: 1174551-05-3
• Molecular Formula: C₁₅H₁₀FNO₂
• Molecular Weight: 255.248
• Mol file: 1174551-05-3.mol

Synonyms:2-amino-3-(4'-fluorobenzoyl)benzo[b]furan

Chemical Property of 2-amino-3-(4'-fluorobenzoyl)benzo[b]furan

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 2-amino-3-(4'-fluorobenzoyl)benzo[b]furan

There total 5 articles about 2-amino-3-(4'-fluorobenzoyl)benzo[b]furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-(cyanomethyl)phenyl 4'-fluorobenzoate (1174550-93-6) → 2-amino-3-(4'-fluorobenzoyl)benzo[b]furan (1174551-05-3)

Guidance literature:

With palladium diacetate; zinc; tricyclohexylphosphine; In N,N-dimethyl-formamide; at 100 ℃; for 24h; Inert atmosphere; Molecular sieve;

DOI:10.1039/b904127c

Reference yield: 62.0%

2-(cyanomethyl)-5-methylphenyl benzoate (1174551-02-0) + 2-(cyanomethyl)phenyl 4'-fluorobenzoate (1174550-93-6) → 2-amino-3-benzoyl-6-methylbenzo[b]furan (1174551-15-5) + 2-amino-3-(4'-fluorobenzoyl)benzo[b]furan (1174551-05-3)

Guidance literature:

With palladium diacetate; zinc; tricyclohexylphosphine; In N,N-dimethyl-formamide; at 100 ℃; for 48h; Inert atmosphere; Molecular sieve;

DOI:10.1039/b904127c

Reference yield: 60.0%

carbon monoxide (201230-82-2) + 2-hydroxybenzyl cyanide (14714-50-2) + 1-Bromo-4-fluorobenzene (460-00-4) → 2-amino-3-(4'-fluorobenzoyl)benzo[b]furan (1174551-05-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium⁽⁰⁾bis(tricyclohexylphosphine); triethylamine; In N,N-dimethyl-formamide; at 100 ℃; for 40h; under 760.051 Torr;

DOI:10.1016/j.tet.2015.04.049

upstream raw materials:

2-(cyanomethyl)-5-methylphenyl benzoate

2-(cyanomethyl)phenyl 4'-fluorobenzoate

salicylic alcohol

salicylic acid